TTC37 [The Human Chemical-Genetic Interaction Map Project]

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======= TTC37 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TTC37
  * **<color #00a2e8>Official Name</color>**: tetratricopeptide repeat domain 37
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9652|9652]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6PGP7|Q6PGP7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TTC37&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TTC37|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein with twenty tetratricopeptide (TPR) repeats. Tetratricopeptide repeat containing motifs are found in a variety of proteins and may mediate protein-protein interactions and chaperone activity. Mutations in this gene are associated with trichohepatoenteric syndrome. [provided by RefSeq, Jul 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TPR 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Ski complex|
|transcriptionally active chromatin|
|exonucleolytic catabolism of deadenylated mRNA|
|nuclear-transcribed mRNA catabolic process, exonucleolytic|
|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|RNA catabolic process|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|mRNA metabolic process|
|cellular macromolecule catabolic process|
|macromolecule catabolic process|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp453|B02 10μM R08 exp453]]|-4.26|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-3.12|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-2.41|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.9|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.86|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.76|
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|-1.75|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.73|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-1.71|
|[[:results:exp132|Metformin 40μM R03 exp132]]|1.71|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.72|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.75|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.77|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.79|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|1.89|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.9|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.03|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|2.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8645
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TTC37 Expression in NALM6 Cells: 7.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>