TTC4 [The Human Chemical-Genetic Interaction Map Project]

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======= TTC4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TTC4
  * **<color #00a2e8>Official Name</color>**: tetratricopeptide repeat domain 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7268|7268]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95801|O95801]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TTC4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TTC4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606753|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions and chaperone activity. The encoded protein interacts with heat shock proteins 70 and 90. Alternative splicing results in multiple transcript variants. Naturally-occuring readthrough transcription occurs from upstream gene MROH (maestro heat-like repeat family member 7) to this gene. [provided by RefSeq, Apr 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-2.29|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|-2.16|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.96|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-1.83|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.79|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.78|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.84|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|2|
|[[:results:exp224|CB-839 10μM R05 exp224]]|2.04|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.31|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.645|
|[[:human genes:a:atxn10|ATXN10]]|0.59|
|[[:human genes:d:dpagt1|DPAGT1]]|0.573|
|[[:human genes:v:vezt|VEZT]]|0.555|
|[[:human genes:p:pmm2|PMM2]]|0.546|
|[[:human genes:u:uap1|UAP1]]|0.544|
|[[:human genes:o:oraov1|ORAOV1]]|0.527|
|[[:human genes:a:alg2|ALG2]]|0.523|
|[[:human genes:a:alg1|ALG1]]|0.519|
|[[:human genes:p:ppcs|PPCS]]|0.507|
|[[:human genes:r:rpp21|RPP21]]|0.504|
|[[:human genes:d:dohh|DOHH]]|0.499|
|[[:human genes:p:pdap1|PDAP1]]|0.497|
|[[:human genes:r:rnmt|RNMT]]|0.496|
|[[:human genes:g:gemin6|GEMIN6]]|0.491|
|[[:human genes:r:rpia|RPIA]]|0.491|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.484|
|[[:human genes:r:rptor|RPTOR]]|0.481|
|[[:human genes:g:gemin8|GEMIN8]]|0.48|
|[[:human genes:t:trmt5|TRMT5]]|0.479|
|[[:human genes:g:gmppb|GMPPB]]|0.478|
|[[:human genes:z:zrsr2|ZRSR2]]|0.474|
|[[:human genes:t:triap1|TRIAP1]]|0.464|
|[[:human genes:t:txnrd1|TXNRD1]]|0.463|
|[[:human genes:t:tbcb|TBCB]]|0.46|
|[[:human genes:c:c15orf41|C15orf41]]|0.456|
|[[:human genes:d:ddx39a|DDX39A]]|0.455|
|[[:human genes:a:atic|ATIC]]|0.455|
|[[:human genes:f:fh|FH]]|0.455|
|[[:human genes:e:eef1e1|EEF1E1]]|0.453|
|[[:human genes:e:elac2|ELAC2]]|0.452|
|[[:human genes:d:dr1|DR1]]|0.452|
|[[:human genes:u:uba3|UBA3]]|0.451|
|[[:human genes:g:gfpt1|GFPT1]]|0.45|
|[[:human genes:r:rabggtb|RABGGTB]]|0.448|
|[[:human genes:r:rtcb|RTCB]]|0.448|
|[[:human genes:t:trmt61a|TRMT61A]]|0.448|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.447|
|[[:human genes:b:bap1|BAP1]]|0.447|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.446|
|[[:human genes:u:uxt|UXT]]|0.446|
|[[:human genes:e:elp3|ELP3]]|0.445|
|[[:human genes:r:rbfa|RBFA]]|0.445|
|[[:human genes:s:srp14|SRP14]]|0.445|
|[[:human genes:p:ppp6c|PPP6C]]|0.444|
|[[:human genes:s:slc25a26|SLC25A26]]|0.443|
|[[:human genes:l:lsm11|LSM11]]|0.441|
|[[:human genes:g:gemin7|GEMIN7]]|0.441|
|[[:human genes:n:nae1|NAE1]]|0.44|
|[[:human genes:r:rfk|RFK]]|0.439|
|[[:human genes:e:exoc4|EXOC4]]|0.439|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.437|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.435|
|[[:human genes:t:tpk1|TPK1]]|0.434|
|[[:human genes:s:ssb|SSB]]|0.433|
|[[:human genes:d:dnlz|DNLZ]]|0.433|
|[[:human genes:d:dhps|DHPS]]|0.432|
|[[:human genes:y:yars|YARS]]|0.43|
|[[:human genes:u:urm1|URM1]]|0.43|
|[[:human genes:r:romo1|ROMO1]]|0.429|
|[[:human genes:c:cep57|CEP57]]|0.428|
|[[:human genes:t:trmt10a|TRMT10A]]|0.428|
|[[:human genes:l:lsm10|LSM10]]|0.427|
|[[:human genes:m:mrps5|MRPS5]]|0.425|
|[[:human genes:d:dhrsx|DHRSX]]|0.425|
|[[:human genes:a:alg13|ALG13]]|0.425|
|[[:human genes:c:cbx3|CBX3]]|0.424|
|[[:human genes:u:uhrf1|UHRF1]]|0.424|
|[[:human genes:d:ddx20|DDX20]]|0.422|
|[[:human genes:p:ppcdc|PPCDC]]|0.421|
|[[:human genes:t:trnt1|TRNT1]]|0.42|
|[[:human genes:m:mbtps2|MBTPS2]]|0.42|
|[[:human genes:s:sec62|SEC62]]|0.419|
|[[:human genes:t:ten1|TEN1]]|0.418|
|[[:human genes:t:tsen54|TSEN54]]|0.418|
|[[:human genes:r:rft1|RFT1]]|0.418|
|[[:human genes:u:utp23|UTP23]]|0.417|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.417|
|[[:human genes:a:adsl|ADSL]]|0.415|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.415|
|[[:human genes:m:med4|MED4]]|0.414|
|[[:human genes:h:hccs|HCCS]]|0.413|
|[[:human genes:t:tamm41|TAMM41]]|0.412|
|[[:human genes:t:txnl4b|TXNL4B]]|0.412|
|[[:human genes:d:dolk|DOLK]]|0.412|
|[[:human genes:m:med16|MED16]]|0.409|
|[[:human genes:d:dap3|DAP3]]|0.407|
|[[:human genes:n:nsd1|NSD1]]|0.406|
|[[:human genes:m:mrpl21|MRPL21]]|0.406|
|[[:human genes:t:tti2|TTI2]]|0.405|
|[[:human genes:t:tsen34|TSEN34]]|0.404|
|[[:human genes:c:chchd4|CHCHD4]]|0.402|
|[[:human genes:n:nbn|NBN]]|0.402|
|[[:human genes:s:srd5a3|SRD5A3]]|0.401|
|[[:human genes:h:hspd1|HSPD1]]|0.401|
|[[:human genes:t:tti1|TTI1]]|0.401|
|[[:human genes:l:lmo2|LMO2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 197/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|7/28|
|blood|3/28|
|bone|9/26|
|breast|5/33|
|central nervous system|21/56|
|cervix|0/4|
|colorectal|6/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|10/21|
|liver|4/20|
|lung|22/75|
|lymphocyte|5/16|
|ovary|6/26|
|pancreas|4/24|
|peripheral nervous system|5/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|5/9|
|thyroid|2/2|
|upper aerodigestive|9/22|
|urinary tract|8/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5038
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TTC4 Expression in NALM6 Cells: 4.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>