TTI1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= TTI1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TTI1
  * **<color #00a2e8>Official Name</color>**: TELO2 interacting protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9675|9675]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43156|O43156]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TTI1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TTI1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614425|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. {ECO:0000269|PubMed:20427287, ECO:0000269|PubMed:20801936, ECO:0000269|PubMed:20810650}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ASTRA complex|
|TORC1 complex|
|TORC2 complex|
|regulation of TOR signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.19|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-2.18|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.81|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-1.78|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.77|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-1.74|
|[[:results:exp149|SB203580 25μM R03 exp149]]|-1.71|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.85|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.96|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.98|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.99|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.01|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|2.25|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.77|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.84|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gnb1l|GNB1L]]|0.679|
|[[:human genes:t:tti2|TTI2]]|0.652|
|[[:human genes:m:med16|MED16]]|0.621|
|[[:human genes:t:telo2|TELO2]]|0.612|
|[[:human genes:r:rnmt|RNMT]]|0.59|
|[[:human genes:t:trmt5|TRMT5]]|0.587|
|[[:human genes:r:rptor|RPTOR]]|0.563|
|[[:human genes:d:dpagt1|DPAGT1]]|0.56|
|[[:human genes:c:ccdc101|CCDC101]]|0.56|
|[[:human genes:a:alg2|ALG2]]|0.558|
|[[:human genes:p:pmm2|PMM2]]|0.558|
|[[:human genes:g:gmppb|GMPPB]]|0.557|
|[[:human genes:a:aars|AARS]]|0.555|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.541|
|[[:human genes:p:polr3h|POLR3H]]|0.541|
|[[:human genes:a:alg1|ALG1]]|0.535|
|[[:human genes:r:rtcb|RTCB]]|0.529|
|[[:human genes:t:thg1l|THG1L]]|0.527|
|[[:human genes:u:uhrf1|UHRF1]]|0.525|
|[[:human genes:m:mllt1|MLLT1]]|0.524|
|[[:human genes:c:csnk2b|CSNK2B]]|0.513|
|[[:human genes:p:ppp4c|PPP4C]]|0.512|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.51|
|[[:human genes:e:eprs|EPRS]]|0.509|
|[[:human genes:g:gfpt1|GFPT1]]|0.505|
|[[:human genes:a:adsl|ADSL]]|0.503|
|[[:human genes:m:med23|MED23]]|0.501|
|[[:human genes:c:cbfb|CBFB]]|0.5|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.494|
|[[:human genes:a:atxn10|ATXN10]]|0.493|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.491|
|[[:human genes:w:wdr24|WDR24]]|0.49|
|[[:human genes:b:bap1|BAP1]]|0.488|
|[[:human genes:m:mapk14|MAPK14]]|0.486|
|[[:human genes:d:dad1|DAD1]]|0.482|
|[[:human genes:p:pelo|PELO]]|0.481|
|[[:human genes:v:vmp1|VMP1]]|0.481|
|[[:human genes:r:rpp21|RPP21]]|0.479|
|[[:human genes:s:srp14|SRP14]]|0.478|
|[[:human genes:e:elac2|ELAC2]]|0.478|
|[[:human genes:m:mtor|MTOR]]|0.477|
|[[:human genes:n:nars|NARS]]|0.474|
|[[:human genes:p:polr3b|POLR3B]]|0.474|
|[[:human genes:d:dohh|DOHH]]|0.473|
|[[:human genes:s:seh1l|SEH1L]]|0.471|
|[[:human genes:s:srp68|SRP68]]|0.469|
|[[:human genes:c:cct7|CCT7]]|0.469|
|[[:human genes:u:uap1|UAP1]]|0.468|
|[[:human genes:p:pax5|PAX5]]|0.463|
|[[:human genes:s:snapc5|SNAPC5]]|0.462|
|[[:human genes:g:gpn2|GPN2]]|0.46|
|[[:human genes:y:yars|YARS]]|0.456|
|[[:human genes:t:tmem41b|TMEM41B]]|0.456|
|[[:human genes:o:otud5|OTUD5]]|0.455|
|[[:human genes:a:alg13|ALG13]]|0.454|
|[[:human genes:u:uxt|UXT]]|0.451|
|[[:human genes:o:osgep|OSGEP]]|0.451|
|[[:human genes:c:cbx3|CBX3]]|0.45|
|[[:human genes:d:ddx20|DDX20]]|0.449|
|[[:human genes:s:slc25a19|SLC25A19]]|0.447|
|[[:human genes:z:zrsr2|ZRSR2]]|0.446|
|[[:human genes:d:dnajc3|DNAJC3]]|0.445|
|[[:human genes:l:lsm11|LSM11]]|0.444|
|[[:human genes:e:eif4e|EIF4E]]|0.44|
|[[:human genes:t:triap1|TRIAP1]]|0.44|
|[[:human genes:f:fnta|FNTA]]|0.439|
|[[:human genes:t:tle4|TLE4]]|0.439|
|[[:human genes:s:srp72|SRP72]]|0.437|
|[[:human genes:n:nae1|NAE1]]|0.437|
|[[:human genes:a:atp5j|ATP5J]]|0.435|
|[[:human genes:c:crcp|CRCP]]|0.432|
|[[:human genes:p:polr3c|POLR3C]]|0.43|
|[[:human genes:a:alg5|ALG5]]|0.427|
|[[:human genes:t:thoc6|THOC6]]|0.427|
|[[:human genes:e:exoc4|EXOC4]]|0.427|
|[[:human genes:w:wdr59|WDR59]]|0.426|
|[[:human genes:u:uba3|UBA3]]|0.426|
|[[:human genes:z:znf259|ZNF259]]|0.426|
|[[:human genes:n:nsmce1|NSMCE1]]|0.426|
|[[:human genes:s:slc35b1|SLC35B1]]|0.423|
|[[:human genes:d:dr1|DR1]]|0.423|
|[[:human genes:s:spcs2|SPCS2]]|0.422|
|[[:human genes:m:med4|MED4]]|0.42|
|[[:human genes:t:tbcb|TBCB]]|0.419|
|[[:human genes:w:wdr82|WDR82]]|0.419|
|[[:human genes:t:tsen54|TSEN54]]|0.418|
|[[:human genes:h:hars|HARS]]|0.417|
|[[:human genes:r:rbm14|RBM14]]|0.417|
|[[:human genes:d:ddost|DDOST]]|0.416|
|[[:human genes:v:vrk1|VRK1]]|0.415|
|[[:human genes:a:atf7ip|ATF7IP]]|0.415|
|[[:human genes:b:bub3|BUB3]]|0.415|
|[[:human genes:n:nup50|NUP50]]|0.414|
|[[:human genes:r:rfk|RFK]]|0.41|
|[[:human genes:u:ubr5|UBR5]]|0.409|
|[[:human genes:h:hspa9|HSPA9]]|0.408|
|[[:human genes:r:rad1|RAD1]]|0.407|
|[[:human genes:s:smarcd1|SMARCD1]]|0.406|
|[[:human genes:t:tsen34|TSEN34]]|0.406|
|[[:human genes:a:alg6|ALG6]]|0.405|
|[[:human genes:e:eny2|ENY2]]|0.405|
|[[:human genes:h:hspd1|HSPD1]]|0.404|
|[[:human genes:e:exoc3|EXOC3]]|0.403|
|[[:human genes:a:atp5o|ATP5O]]|0.403|
|[[:human genes:d:dhps|DHPS]]|0.402|
|[[:human genes:t:tamm41|TAMM41]]|0.402|
|[[:human genes:t:ttc4|TTC4]]|0.401|
|[[:human genes:c:ciao1|CIAO1]]|0.401|
|[[:human genes:a:atp5b|ATP5B]]|0.4|
|[[:human genes:i:id3|ID3]]|0.4|
|[[:human genes:t:taf5l|TAF5L]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 424/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|15/28|
|blood|19/28|
|bone|23/26|
|breast|17/33|
|central nervous system|35/56|
|cervix|1/4|
|colorectal|11/17|
|esophagus|7/13|
|fibroblast|1/1|
|gastric|9/16|
|kidney|11/21|
|liver|14/20|
|lung|45/75|
|lymphocyte|7/16|
|ovary|16/26|
|pancreas|10/24|
|peripheral nervous system|12/16|
|plasma cell|10/15|
|prostate|1/1|
|skin|14/24|
|soft tissue|4/9|
|thyroid|2/2|
|upper aerodigestive|9/22|
|urinary tract|15/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 175
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TTI1 Expression in NALM6 Cells: 6.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>