TTK [The Human Chemical-Genetic Interaction Map Project]

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======= TTK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TTK
  * **<color #00a2e8>Official Name</color>**: TTK protein kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7272|7272]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P33981|P33981]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TTK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TTK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604092|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint. {ECO:0000269|PubMed:18243099}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to meiotic spindle midzone|
|protein localization to meiotic spindle|
|meiotic spindle checkpoint|
|meiotic spindle assembly checkpoint|
|negative regulation of metaphase/anaphase transition of meiotic cell cycle|
|negative regulation of meiotic chromosome separation|
|regulation of meiotic chromosome separation|
|negative regulation of meiotic cell cycle phase transition|
|regulation of metaphase/anaphase transition of meiotic cell cycle|
|kinetochore binding|
|female meiosis chromosome segregation|
|meiotic cell cycle checkpoint|
|regulation of meiotic cell cycle phase transition|
|negative regulation of meiotic nuclear division|
|protein localization to kinetochore|
|negative regulation of meiotic cell cycle|
|protein localization to chromosome, centromeric region|
|mitotic spindle assembly checkpoint|
|spindle checkpoint|
|spindle assembly checkpoint|
|mitotic spindle checkpoint|
|negative regulation of mitotic metaphase/anaphase transition|
|negative regulation of metaphase/anaphase transition of cell cycle|
|negative regulation of mitotic sister chromatid separation|
|negative regulation of chromosome separation|
|protein serine/threonine/tyrosine kinase activity|
|negative regulation of mitotic sister chromatid segregation|
|regulation of meiotic nuclear division|
|female meiotic nuclear division|
|chromosome separation|
|negative regulation of sister chromatid segregation|
|negative regulation of chromosome segregation|
|protein localization to microtubule cytoskeleton|
|protein localization to cytoskeleton|
|negative regulation of mitotic nuclear division|
|negative regulation of nuclear division|
|positive regulation of pathway-restricted SMAD protein phosphorylation|
|regulation of meiotic cell cycle|
|regulation of mitotic metaphase/anaphase transition|
|regulation of metaphase/anaphase transition of cell cycle|
|negative regulation of reproductive process|
|regulation of mitotic sister chromatid separation|
|regulation of pathway-restricted SMAD protein phosphorylation|
|protein localization to chromosome|
|regulation of chromosome separation|
|regulation of mitotic sister chromatid segregation|
|mitotic spindle organization|
|regulation of sister chromatid segregation|
|peptidyl-threonine phosphorylation|
|kinetochore|
|protein tyrosine kinase activity|
|meiotic chromosome segregation|
|peptidyl-threonine modification|
|regulation of chromosome segregation|
|microtubule cytoskeleton organization involved in mitosis|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|spindle|
|female gamete generation|
|negative regulation of chromosome organization|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|meiotic nuclear division|
|mitotic cell cycle checkpoint|
|spindle organization|
|regulation of reproductive process|
|meiotic cell cycle process|
|regulation of mitotic nuclear division|
|peptidyl-serine phosphorylation|
|regulation of nuclear division|
|cell cycle checkpoint|
|protein autophosphorylation|
|peptidyl-serine modification|
|negative regulation of mitotic cell cycle phase transition|
|nuclear chromosome segregation|
|meiotic cell cycle|
|negative regulation of cell cycle phase transition|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|chromosome segregation|
|nuclear division|
|negative regulation of mitotic cell cycle|
|organelle fission|
|negative regulation of cell cycle process|
|regulation of chromosome organization|
|cellular process involved in reproduction in multicellular organism|
|protein serine/threonine kinase activity|
|negative regulation of organelle organization|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|microtubule cytoskeleton organization|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|gamete generation|
|negative regulation of cellular component organization|
|protein localization to organelle|
|regulation of cell cycle process|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|positive regulation of cell population proliferation|
|protein phosphorylation|
|multi-organism reproductive process|
|cell cycle process|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|cytoskeleton organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of cell cycle|
|positive regulation of protein modification process|
|phosphorylation|
|regulation of organelle organization|
|cell cycle|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|ATP binding|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.47|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-2.21|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.11|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.91|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.85|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.82|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.78|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.7|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.74|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|1.75|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|1.83|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.92|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|1.92|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.97|
|[[:results:exp210|LB-100 2μM R05 exp210]]|2.01|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.04|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.09|
|[[:results:exp340|BN82002 4μM R07 exp340]]|2.15|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.22|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|2.23|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.29|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|2.33|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.34|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.34|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.38|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.89|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|3.15|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|3.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nup133|NUP133]]|0.452|
|[[:human genes:c:ccna2|CCNA2]]|0.447|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.438|
|[[:human genes:p:polr2j3|POLR2J3]]|0.427|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.419|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.418|
|[[:human genes:t:tspy8|TSPY8]]|0.416|
|[[:human genes:p:psmb4|PSMB4]]|0.415|
|[[:human genes:r:rps12|RPS12]]|0.414|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.41|
|[[:human genes:t:twistnb|TWISTNB]]|0.409|
|[[:human genes:r:rps11|RPS11]]|0.408|
|[[:human genes:c:chd4|CHD4]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 220/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|13/28|
|blood|4/28|
|bone|8/26|
|breast|11/33|
|central nervous system|20/56|
|cervix|3/4|
|colorectal|5/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|6/21|
|liver|4/20|
|lung|29/75|
|lymphocyte|4/16|
|ovary|7/26|
|pancreas|4/24|
|peripheral nervous system|4/16|
|plasma cell|4/15|
|prostate|1/1|
|skin|8/24|
|soft tissue|2/9|
|thyroid|1/2|
|upper aerodigestive|4/22|
|urinary tract|8/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 961
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TTK Expression in NALM6 Cells: 6.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>