TTYH1 [The Human Chemical-Genetic Interaction Map Project]

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======= TTYH1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TTYH1
  * **<color #00a2e8>Official Name</color>**: tweety family member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57348|57348]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H313|Q9H313]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TTYH1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TTYH1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605784|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tweety|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|volume-sensitive chloride channel activity|
|smooth endoplasmic reticulum membrane|
|iron ion transmembrane transporter activity|
|iron ion transmembrane transport|
|intracellular calcium activated chloride channel activity|
|filopodium assembly|
|filopodium tip|
|filopodium membrane|
|chloride channel complex|
|chloride channel activity|
|iron ion transport|
|chloride transmembrane transport|
|chloride transport|
|inorganic anion transmembrane transport|
|transition metal ion transport|
|inorganic anion transport|
|cell-substrate adhesion|
|synapse|
|anion transmembrane transport|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|cell-cell adhesion|
|inorganic cation transmembrane transport|
|anion transport|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|mitotic cell cycle|
|calcium ion binding|
|cation transport|
|cell adhesion|
|biological adhesion|
|ion transmembrane transport|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|transmembrane transport|
|cell cycle|
|ion transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.72|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.71|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|1.79|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|1.99|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|2.07|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:v:vasn|VASN]]|0.485|
|[[:human genes:a:ahctf1|AHCTF1]]|0.447|
|[[:human genes:p:psmd11|PSMD11]]|0.43|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.419|
|[[:human genes:t:tceb3c|TCEB3C]]|0.416|
|[[:human genes:a:aaas|AAAS]]|0.412|
|[[:human genes:p:plk1|PLK1]]|0.411|
|[[:human genes:p:pola2|POLA2]]|0.407|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.405|
|[[:human genes:r:rrp7a|RRP7A]]|0.405|
|[[:human genes:d:ddtl|DDTL]]|0.403|
|[[:human genes:p:psmd3|PSMD3]]|0.402|
|[[:human genes:p:ppfia4|PPFIA4]]|0.401|
|[[:human genes:c:cmya5|CMYA5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2504
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TTYH1 Expression in NALM6 Cells: 3.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>