TUBA1C [The Human Chemical-Genetic Interaction Map Project]

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======= TUBA1C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TUBA1C
  * **<color #00a2e8>Official Name</color>**: tubulin alpha 1c
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84790|84790]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BQE3|Q9BQE3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TUBA1C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TUBA1C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/621161|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tubulin|
|Tubulin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|structural constituent of cytoskeleton|
|vesicle|
|microtubule cytoskeleton|
|cytoskeleton-dependent intracellular transport|
|structural molecule activity|
|microtubule|
|GTPase activity|
|GTP binding|
|microtubule cytoskeleton organization|
|cell division|
|microtubule-based process|
|mitotic cell cycle|
|cytoskeleton organization|
|cell cycle|
|intracellular transport|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.16|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.92|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-1.91|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-1.82|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.82|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.95|
|[[:results:exp169|BH1 1μM R04 exp169]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 197/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|11/28|
|blood|1/28|
|bone|5/26|
|breast|15/33|
|central nervous system|18/56|
|cervix|2/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|11/21|
|liver|10/20|
|lung|13/75|
|lymphocyte|2/16|
|ovary|6/26|
|pancreas|7/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|7/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|10/22|
|urinary tract|11/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3416
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TUBA1C Expression in NALM6 Cells: 8.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>