TUBB4B [The Human Chemical-Genetic Interaction Map Project]

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======= TUBB4B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TUBB4B
  * **<color #00a2e8>Official Name</color>**: tubulin beta 4B class IVb
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10383|10383]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P68371|P68371]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TUBB4B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TUBB4B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602660|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tubulin C|
|Tubulin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|MHC class I protein binding|
|natural killer cell mediated cytotoxicity|
|natural killer cell mediated immunity|
|leukocyte mediated cytotoxicity|
|extracellular vesicle|
|double-stranded RNA binding|
|cell killing|
|azurophil granule lumen|
|ciliary basal body-plasma membrane docking|
|structural constituent of cytoskeleton|
|G2/M transition of mitotic cell cycle|
|unfolded protein binding|
|cell cycle G2/M phase transition|
|organelle localization by membrane tethering|
|membrane docking|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|lymphocyte mediated immunity|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|microtubule|
|GTPase activity|
|cilium assembly|
|cytoskeleton|
|cilium organization|
|GTP binding|
|regulation of mitotic cell cycle phase transition|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|cell projection assembly|
|microtubule cytoskeleton organization|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|organelle localization|
|myeloid leukocyte activation|
|mitotic cell cycle process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|regulated exocytosis|
|regulation of cell cycle process|
|organelle assembly|
|innate immune response|
|leukocyte mediated immunity|
|exocytosis|
|leukocyte activation|
|defense response to other organism|
|cell cycle process|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|secretion|
|cell projection organization|
|regulation of cell cycle|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|cell cycle|
|defense response|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-3.13|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-3.02|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.97|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.81|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.85|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.72|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|3.75|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|5.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:v:vbp1|VBP1]]|0.437|
|[[:human genes:s:ska1|SKA1]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 39/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|1/21|
|liver|1/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|4/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3902
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TUBB4B Expression in NALM6 Cells: 8.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>