TWSG1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= TWSG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TWSG1
  * **<color #00a2e8>Official Name</color>**: twisted gastrulation BMP signaling modulator 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57045|57045]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9GZX9|Q9GZX9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TWSG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TWSG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605049|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tsg|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of CD4-positive, alpha-beta T cell proliferation|
|negative regulation of alpha-beta T cell proliferation|
|regulation of CD4-positive, alpha-beta T cell proliferation|
|transforming growth factor beta binding|
|salivary gland morphogenesis|
|negative regulation of CD4-positive, alpha-beta T cell activation|
|regulation of alpha-beta T cell proliferation|
|positive regulation of BMP signaling pathway|
|salivary gland development|
|negative regulation of alpha-beta T cell activation|
|exocrine system development|
|negative regulation of osteoblast differentiation|
|positive regulation of pathway-restricted SMAD protein phosphorylation|
|negative regulation of BMP signaling pathway|
|negative regulation of T cell proliferation|
|regulation of CD4-positive, alpha-beta T cell activation|
|regulation of pathway-restricted SMAD protein phosphorylation|
|mesoderm formation|
|mesoderm morphogenesis|
|negative regulation of ossification|
|negative regulation of mononuclear cell proliferation|
|negative regulation of lymphocyte proliferation|
|negative regulation of leukocyte proliferation|
|regulation of BMP signaling pathway|
|BMP signaling pathway|
|regulation of alpha-beta T cell activation|
|gland morphogenesis|
|transforming growth factor beta receptor signaling pathway|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cellular response to BMP stimulus|
|response to BMP|
|negative regulation of T cell activation|
|formation of primary germ layer|
|regulation of osteoblast differentiation|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|negative regulation of leukocyte cell-cell adhesion|
|mesoderm development|
|negative regulation of lymphocyte activation|
|negative regulation of cellular response to growth factor stimulus|
|cellular response to transforming growth factor beta stimulus|
|regulation of T cell proliferation|
|gastrulation|
|response to transforming growth factor beta|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|regulation of ossification|
|negative regulation of cell activation|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of leukocyte proliferation|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|ossification|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|regulation of leukocyte cell-cell adhesion|
|camera-type eye development|
|regulation of T cell activation|
|eye development|
|visual system development|
|sensory system development|
|forebrain development|
|regulation of cell-cell adhesion|
|gland development|
|negative regulation of immune system process|
|cellular response to growth factor stimulus|
|regulation of lymphocyte activation|
|response to growth factor|
|sensory organ development|
|hemopoiesis|
|tissue morphogenesis|
|embryonic morphogenesis|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|regulation of cell activation|
|immune system development|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of cytokine production|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|brain development|
|head development|
|anatomical structure formation involved in morphogenesis|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15687
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TWSG1 Expression in NALM6 Cells: 4.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>