TXN [The Human Chemical-Genetic Interaction Map Project]

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======= TXN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TXN
  * **<color #00a2e8>Official Name</color>**: thioredoxin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7295|7295]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10599|P10599]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TXN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TXN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/187700|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Thioredoxin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of protein export from nucleus|
|thioredoxin-disulfide reductase activity|
|peptide disulfide oxidoreductase activity|
|glycerol ether metabolic process|
|negative regulation of hydrogen peroxide-induced cell death|
|negative regulation of response to reactive oxygen species|
|ether metabolic process|
|negative regulation of nucleocytoplasmic transport|
|negative regulation of cellular response to drug|
|maintenance of protein location in nucleus|
|regulation of hydrogen peroxide-induced cell death|
|protein disulfide oxidoreductase activity|
|negative regulation of response to drug|
|activation of protein kinase B activity|
|regulation of response to reactive oxygen species|
|regulation of cellular response to drug|
|regulation of protein export from nucleus|
|maintenance of protein localization in organelle|
|negative regulation of intracellular protein transport|
|negative regulation of oxidative stress-induced cell death|
|negative regulation of cellular response to oxidative stress|
|negative regulation of response to oxidative stress|
|positive regulation of DNA binding|
|negative regulation of intracellular transport|
|regulation of oxidative stress-induced cell death|
|regulation of cellular response to oxidative stress|
|maintenance of protein location in cell|
|cell redox homeostasis|
|regulation of response to oxidative stress|
|cellular oxidant detoxification|
|maintenance of location in cell|
|regulation of response to drug|
|cellular detoxification|
|positive regulation of peptidyl-serine phosphorylation|
|maintenance of protein location|
|regulation of nucleocytoplasmic transport|
|negative regulation of cellular protein localization|
|regulation of DNA binding|
|detoxification|
|regulation of peptidyl-serine phosphorylation|
|protein localization to nucleus|
|maintenance of location|
|positive regulation of protein kinase B signaling|
|positive regulation of binding|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|cellular response to toxic substance|
|regulation of protein kinase B signaling|
|regulation of intracellular protein transport|
|activation of protein kinase activity|
|regulation of intracellular transport|
|regulation of binding|
|response to radiation|
|negative regulation of transport|
|response to toxic substance|
|positive regulation of protein kinase activity|
|regulation of cellular protein localization|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|regulation of protein transport|
|protein localization to organelle|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of protein kinase activity|
|negative regulation of transcription by RNA polymerase II|
|regulation of kinase activity|
|cellular homeostasis|
|regulation of cellular localization|
|oxidation-reduction process|
|regulation of transferase activity|
|negative regulation of cell death|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|positive regulation of phosphorylation|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|small molecule metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.08|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.89|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 710/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|28/28|
|bone|25/26|
|breast|31/33|
|central nervous system|54/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|19/20|
|lung|74/75|
|lymphocyte|15/16|
|ovary|24/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2115
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TXN Expression in NALM6 Cells: 5.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>