TXNL4A [The Human Chemical-Genetic Interaction Map Project]

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======= TXNL4A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TXNL4A
  * **<color #00a2e8>Official Name</color>**: thioredoxin like 4A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10907|10907]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P83876|P83876]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TXNL4A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TXNL4A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611595|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the U5 small ribonucleoprotein particle (snRNP), and is involved in pre-mRNA splicing. This protein contains a thioredoxin-like fold and it is expected to interact with multiple proteins. Protein-protein interactions have been observed with the polyglutamine tract-binding protein 1 (PQBP1). Mutations in both the coding region and promoter region of this gene have been associated with Burn-McKeown syndrome, which is a rare disorder characterized by craniofacial dysmorphisms, cardiac defects, hearing loss, and bilateral choanal atresia. A pseudogene of this gene is found on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly. {ECO:0000269|PubMed:10610776}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Thioredoxin|
|DIM1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U5 snRNP|
|U4/U6 x U5 tri-snRNP complex|
|U2-type precatalytic spliceosome|
|spliceosomal complex assembly|
|spliceosomal complex|
|ribonucleoprotein complex assembly|
|nuclear membrane|
|ribonucleoprotein complex subunit organization|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|cell division|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|cell cycle|
|protein-containing complex assembly|
|RNA metabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-3.25|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2.39|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.89|
|[[:results:exp16|DABN 2μM R00 exp16]]|-1.86|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.82|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.71|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.71|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.72|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.83|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|1.9|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.92|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 53
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TXNL4A Expression in NALM6 Cells: 6.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>