TYROBP [The Human Chemical-Genetic Interaction Map Project]

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======= TYROBP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TYROBP
  * **<color #00a2e8>Official Name</color>**: transmembrane immune signaling adaptor TYROBP
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7305|7305]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43914|O43914]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TYROBP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TYROBP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604142|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of hippocampal neuron apoptotic process|
|negative regulation of interleukin-10 biosynthetic process|
|positive regulation of microglial cell mediated cytotoxicity|
|regulation of microglial cell mediated cytotoxicity|
|positive regulation of receptor localization to synapse|
|microglial cell activation involved in immune response|
|positive regulation of osteoclast development|
|regulation of hippocampal neuron apoptotic process|
|regulation of macrophage fusion|
|negative regulation of transforming growth factor beta1 production|
|positive regulation of macrophage fusion|
|regulation of interleukin-10 biosynthetic process|
|regulation of interleukin-1 biosynthetic process|
|positive regulation of interleukin-1 beta biosynthetic process|
|regulation of interleukin-1 beta biosynthetic process|
|positive regulation of interleukin-1 biosynthetic process|
|positive regulation of bone development|
|negative regulation of transforming growth factor beta production|
|positive regulation of protein localization to synapse|
|regulation of osteoclast development|
|regulation of transforming growth factor beta1 production|
|negative regulation of long-term synaptic potentiation|
|macrophage activation involved in immune response|
|positive regulation of interleukin-6 biosynthetic process|
|negative regulation of B cell proliferation|
|positive regulation of protein localization to cell surface|
|regulation of receptor localization to synapse|
|negative regulation of interleukin-10 production|
|positive regulation of superoxide anion generation|
|positive regulation of natural killer cell activation|
|positive regulation of tumor necrosis factor biosynthetic process|
|regulation of superoxide anion generation|
|regulation of interleukin-6 biosynthetic process|
|regulation of bone development|
|positive regulation of osteoclast differentiation|
|regulation of protein localization to synapse|
|positive regulation of syncytium formation by plasma membrane fusion|
|regulation of syncytium formation by plasma membrane fusion|
|negative regulation of B cell activation|
|regulation of tumor necrosis factor biosynthetic process|
|microglial cell activation|
|leukocyte activation involved in inflammatory response|
|negative regulation of cytokine biosynthetic process|
|regulation of natural killer cell activation|
|regulation of superoxide metabolic process|
|regulation of transforming growth factor beta production|
|regulation of protein localization to cell surface|
|glial cell activation|
|apoptotic cell clearance|
|neuroinflammatory response|
|regulation of long-term synaptic potentiation|
|osteoclast differentiation|
|response to axon injury|
|macrophage activation|
|positive regulation of interleukin-1 beta production|
|regulation of interleukin-10 production|
|cellular defense response|
|positive regulation of neuron apoptotic process|
|positive regulation of myeloid leukocyte differentiation|
|positive regulation of leukocyte mediated cytotoxicity|
|positive regulation of interleukin-1 production|
|regulation of B cell proliferation|
|regulation of osteoclast differentiation|
|positive regulation of cytokine biosynthetic process|
|positive regulation of cell killing|
|negative regulation of mononuclear cell proliferation|
|negative regulation of lymphocyte proliferation|
|regulation of leukocyte mediated cytotoxicity|
|negative regulation of leukocyte proliferation|
|cell|
|regulation of interleukin-1 beta production|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of neuron death|
|positive regulation of myeloid cell differentiation|
|integrin-mediated signaling pathway|
|regulation of interleukin-1 production|
|positive regulation of interleukin-6 production|
|positive regulation of reactive oxygen species metabolic process|
|secretory granule membrane|
|regulation of cell killing|
|regulation of cytokine biosynthetic process|
|myeloid leukocyte differentiation|
|regulation of myeloid leukocyte differentiation|
|regulation of interleukin-6 production|
|negative regulation of lymphocyte activation|
|positive regulation of leukocyte differentiation|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|negative regulation of leukocyte activation|
|protein stabilization|
|regulation of reactive oxygen species metabolic process|
|positive regulation of hemopoiesis|
|regulation of synaptic plasticity|
|negative regulation of cell activation|
|regulation of neuron apoptotic process|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|myeloid cell differentiation|
|regulation of leukocyte proliferation|
|regulation of myeloid cell differentiation|
|regulation of leukocyte differentiation|
|negative regulation of cytokine production|
|apoptotic signaling pathway|
|regulation of protein stability|
|regulation of neuron death|
|positive regulation of cellular protein localization|
|phagocytosis|
|leukocyte differentiation|
|signaling receptor binding|
|positive regulation of lymphocyte activation|
|forebrain development|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|negative regulation of immune system process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|actin cytoskeleton organization|
|inflammatory response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|regulation of lymphocyte activation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of cellular protein localization|
|positive regulation of cell development|
|hemopoiesis|
|actin filament-based process|
|response to wounding|
|myeloid leukocyte activation|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|immune system development|
|positive regulation of programmed cell death|
|negative regulation of cell population proliferation|
|regulation of cytokine production|
|positive regulation of cell death|
|regulated exocytosis|
|brain development|
|innate immune response|
|leukocyte mediated immunity|
|head development|
|exocytosis|
|regulation of cellular localization|
|apoptotic process|
|leukocyte activation|
|regulation of cell development|
|defense response to other organism|
|positive regulation of cell differentiation|
|central nervous system development|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|cell activation|
|immune effector process|
|cell death|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|secretion|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|integral component of plasma membrane|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8048
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TYROBP Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>