U2AF1 [The Human Chemical-Genetic Interaction Map Project]

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======= U2AF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: U2AF1
  * **<color #00a2e8>Official Name</color>**: U2 small nuclear RNA auxiliary factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7307|7307]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01081|Q01081]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=U2AF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20U2AF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191317|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron. {ECO:0000269|PubMed:22158538, ECO:0000269|PubMed:25311244, ECO:0000269|PubMed:8647433}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
|zf-CCCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U2AF|
|pre-mRNA 3-splice site binding|
|Cajal body|
|mRNA 3-end processing|
|catalytic step 2 spliceosome|
|spliceosomal complex|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|RNA 3-end processing|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|RNA localization|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|intracellular protein transport|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|RNA metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-2.17|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.16|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-1.89|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.86|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|-1.8|
|[[:results:exp149|SB203580 25μM R03 exp149]]|-1.78|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-1.72|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.71|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|1.71|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.75|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|1.78|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.88|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|1.9|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.94|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.95|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.04|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.12|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|2.13|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|2.23|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 629/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|18/28|
|bone|20/25|
|breast|31/33|
|central nervous system|50/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|14/15|
|kidney|17/21|
|liver|17/20|
|lung|64/75|
|lymphocyte|14/14|
|ovary|19/26|
|pancreas|23/24|
|peripheral nervous system|16/16|
|plasma cell|9/15|
|prostate|1/1|
|skin|21/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|18/22|
|urinary tract|27/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2427
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='U2AF1 Expression in NALM6 Cells: 7.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>