UBASH3B [The Human Chemical-Genetic Interaction Map Project]

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======= UBASH3B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBASH3B
  * **<color #00a2e8>Official Name</color>**: ubiquitin associated and SH3 domain containing B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84959|84959]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TF42|Q8TF42]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBASH3B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBASH3B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609201|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination. {ECO:0000269|PubMed:15159412, ECO:0000269|PubMed:17880946}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|His Phos 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|collagen-activated tyrosine kinase receptor signaling pathway|
|negative regulation of platelet aggregation|
|collagen-activated signaling pathway|
|negative regulation of bone resorption|
|negative regulation of homotypic cell-cell adhesion|
|negative regulation of bone remodeling|
|regulation of platelet aggregation|
|negative regulation of platelet activation|
|negative regulation of tissue remodeling|
|regulation of homotypic cell-cell adhesion|
|negative regulation of osteoclast differentiation|
|regulation of platelet activation|
|phosphoprotein binding|
|regulation of bone resorption|
|platelet aggregation|
|negative regulation of myeloid leukocyte differentiation|
|phosphatase activity|
|regulation of bone remodeling|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|negative regulation of coagulation|
|homotypic cell-cell adhesion|
|regulation of osteoclast differentiation|
|negative regulation of wound healing|
|regulation of tissue remodeling|
|negative regulation of myeloid cell differentiation|
|regulation of release of sequestered calcium ion into cytosol|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|negative regulation of response to wounding|
|regulation of calcium ion transport into cytosol|
|protein tyrosine phosphatase activity|
|negative regulation of leukocyte differentiation|
|peptidyl-tyrosine dephosphorylation|
|regulation of myeloid leukocyte differentiation|
|regulation of sequestering of calcium ion|
|negative regulation of hemopoiesis|
|platelet activation|
|regulation of wound healing|
|regulation of calcium ion transmembrane transport|
|regulation of response to wounding|
|negative regulation of cell-cell adhesion|
|negative regulation of cell activation|
|protein dephosphorylation|
|regulation of protein binding|
|negative regulation of protein kinase activity|
|regulation of myeloid cell differentiation|
|negative regulation of kinase activity|
|regulation of calcium ion transport|
|regulation of leukocyte differentiation|
|negative regulation of cell adhesion|
|negative regulation of transferase activity|
|ubiquitin protein ligase binding|
|blood coagulation|
|coagulation|
|hemostasis|
|dephosphorylation|
|regulation of cation transmembrane transport|
|negative regulation of response to external stimulus|
|regulation of binding|
|regulation of metal ion transport|
|regulation of cell-cell adhesion|
|negative regulation of protein phosphorylation|
|negative regulation of immune system process|
|negative regulation of phosphorylation|
|regulation of hemopoiesis|
|regulation of ion transmembrane transport|
|wound healing|
|regulation of body fluid levels|
|cell-cell adhesion|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|response to wounding|
|negative regulation of protein modification process|
|regulation of cell activation|
|regulation of cell adhesion|
|regulation of ion transport|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|regulation of cellular localization|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|regulation of transferase activity|
|negative regulation of cellular protein metabolic process|
|identical protein binding|
|cell activation|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-2.09|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.75|
|[[:results:exp303|39°C R06 exp303]]|-1.72|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.71|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.79|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13888
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBASH3B Expression in NALM6 Cells: 6.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>