UBE2G2 [The Human Chemical-Genetic Interaction Map Project]

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======= UBE2G2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBE2G2
  * **<color #00a2e8>Official Name</color>**: ubiquitin conjugating enzyme E2 G2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7327|7327]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P60604|P60604]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBE2G2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBE2G2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603124|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Involved in endoplasmic reticulum- associated degradation (ERAD). {ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:22607976}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UQ con|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of retrograde protein transport, ER to cytosol|
|negative regulation of protein exit from endoplasmic reticulum|
|negative regulation of ERAD pathway|
|regulation of retrograde protein transport, ER to cytosol|
|cellular response to interferon-beta|
|regulation of protein exit from endoplasmic reticulum|
|response to interferon-beta|
|regulation of ERAD pathway|
|protein N-linked glycosylation via asparagine|
|peptidyl-asparagine modification|
|ubiquitin conjugating enzyme activity|
|negative regulation of intracellular protein transport|
|negative regulation of response to endoplasmic reticulum stress|
|protein K48-linked ubiquitination|
|negative regulation of proteasomal protein catabolic process|
|negative regulation of intracellular transport|
|ubiquitin-dependent ERAD pathway|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|protein N-linked glycosylation|
|regulation of response to endoplasmic reticulum stress|
|negative regulation of cellular protein catabolic process|
|ERAD pathway|
|negative regulation of cellular protein localization|
|negative regulation of protein catabolic process|
|negative regulation of protein transport|
|regulation of proteasomal protein catabolic process|
|negative regulation of establishment of protein localization|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of intracellular protein transport|
|ubiquitin-protein transferase activity|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|macromolecule glycosylation|
|protein glycosylation|
|response to endoplasmic reticulum stress|
|glycosylation|
|protein polyubiquitination|
|negative regulation of catabolic process|
|glycoprotein biosynthetic process|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|regulation of intracellular transport|
|negative regulation of proteolysis|
|regulation of protein catabolic process|
|glycoprotein metabolic process|
|negative regulation of transport|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|regulation of cellular protein localization|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|carbohydrate derivative biosynthetic process|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|protein modification by small protein conjugation|
|regulation of cellular catabolic process|
|peptidyl-amino acid modification|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|identical protein binding|
|response to nitrogen compound|
|response to cytokine|
|negative regulation of protein metabolic process|
|proteolysis|
|organonitrogen compound biosynthetic process|
|regulation of response to stress|
|ATP binding|
|negative regulation of response to stimulus|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.48|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-2.07|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-1.76|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-1.7|
|[[:results:exp539|42°C R08 exp539]]|1.7|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.71|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.72|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.73|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.73|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.75|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.75|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.78|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.78|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.79|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.86|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.87|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.9|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.94|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.97|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.05|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.05|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.05|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.13|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|2.13|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.16|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.18|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.23|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.24|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.26|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.28|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.31|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|2.37|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.4|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.42|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.48|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.54|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|4.6|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:faf2|FAF2]]|0.671|
|[[:human genes:d:dohh|DOHH]]|0.611|
|[[:human genes:r:rptor|RPTOR]]|0.601|
|[[:human genes:a:aup1|AUP1]]|0.599|
|[[:human genes:u:ube2j1|UBE2J1]]|0.582|
|[[:human genes:d:dnajc3|DNAJC3]]|0.578|
|[[:human genes:a:atp5o|ATP5O]]|0.573|
|[[:human genes:r:romo1|ROMO1]]|0.563|
|[[:human genes:t:thg1l|THG1L]]|0.557|
|[[:human genes:p:pmm2|PMM2]]|0.556|
|[[:human genes:m:manf|MANF]]|0.554|
|[[:human genes:p:plaa|PLAA]]|0.553|
|[[:human genes:a:atp5j|ATP5J]]|0.552|
|[[:human genes:r:rnmt|RNMT]]|0.55|
|[[:human genes:a:alg5|ALG5]]|0.544|
|[[:human genes:a:atp5a1|ATP5A1]]|0.54|
|[[:human genes:g:gfpt1|GFPT1]]|0.537|
|[[:human genes:t:triap1|TRIAP1]]|0.535|
|[[:human genes:d:dpagt1|DPAGT1]]|0.534|
|[[:human genes:a:alg1|ALG1]]|0.534|
|[[:human genes:u:uap1|UAP1]]|0.534|
|[[:human genes:c:cbfb|CBFB]]|0.529|
|[[:human genes:a:atp5b|ATP5B]]|0.527|
|[[:human genes:e:eny2|ENY2]]|0.524|
|[[:human genes:w:wdr24|WDR24]]|0.522|
|[[:human genes:h:hspd1|HSPD1]]|0.517|
|[[:human genes:s:srp14|SRP14]]|0.514|
|[[:human genes:t:tmed10|TMED10]]|0.513|
|[[:human genes:s:sec62|SEC62]]|0.511|
|[[:human genes:d:dolk|DOLK]]|0.508|
|[[:human genes:d:derl2|DERL2]]|0.504|
|[[:human genes:b:bap1|BAP1]]|0.504|
|[[:human genes:o:opa1|OPA1]]|0.503|
|[[:human genes:e:elp3|ELP3]]|0.502|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.501|
|[[:human genes:k:kdsr|KDSR]]|0.5|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.499|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.498|
|[[:human genes:s:suv420h1|SUV420H1]]|0.498|
|[[:human genes:i:id3|ID3]]|0.497|
|[[:human genes:g:gmppb|GMPPB]]|0.497|
|[[:human genes:a:alg6|ALG6]]|0.497|
|[[:human genes:u:uba5|UBA5]]|0.491|
|[[:human genes:m:mtor|MTOR]]|0.491|
|[[:human genes:c:crls1|CRLS1]]|0.49|
|[[:human genes:n:nsd1|NSD1]]|0.49|
|[[:human genes:c:ccdc101|CCDC101]]|0.488|
|[[:human genes:u:ufm1|UFM1]]|0.486|
|[[:human genes:r:rtcb|RTCB]]|0.482|
|[[:human genes:t:trim28|TRIM28]]|0.482|
|[[:human genes:d:dnajb11|DNAJB11]]|0.481|
|[[:human genes:t:taz|TAZ]]|0.48|
|[[:human genes:s:sec63|SEC63]]|0.478|
|[[:human genes:a:atp5i|ATP5I]]|0.478|
|[[:human genes:t:taf4|TAF4]]|0.477|
|[[:human genes:g:gnb1l|GNB1L]]|0.477|
|[[:human genes:a:atp5d|ATP5D]]|0.476|
|[[:human genes:s:stt3a|STT3A]]|0.476|
|[[:human genes:s:ssb|SSB]]|0.475|
|[[:human genes:a:alg13|ALG13]]|0.474|
|[[:human genes:m:med16|MED16]]|0.473|
|[[:human genes:a:apaf1|APAF1]]|0.471|
|[[:human genes:u:ufc1|UFC1]]|0.47|
|[[:human genes:v:vmp1|VMP1]]|0.469|
|[[:human genes:x:xpo6|XPO6]]|0.467|
|[[:human genes:e:exoc4|EXOC4]]|0.466|
|[[:human genes:u:ube2m|UBE2M]]|0.464|
|[[:human genes:d:dhrsx|DHRSX]]|0.462|
|[[:human genes:c:casp9|CASP9]]|0.461|
|[[:human genes:t:timm13|TIMM13]]|0.46|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.459|
|[[:human genes:p:ppa2|PPA2]]|0.458|
|[[:human genes:b:bak1|BAK1]]|0.457|
|[[:human genes:v:vhl|VHL]]|0.456|
|[[:human genes:c:c1orf27|C1orf27]]|0.455|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.455|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.452|
|[[:human genes:t:trmt10a|TRMT10A]]|0.451|
|[[:human genes:a:adsl|ADSL]]|0.451|
|[[:human genes:d:derl1|DERL1]]|0.45|
|[[:human genes:m:mllt1|MLLT1]]|0.449|
|[[:human genes:t:tmem41b|TMEM41B]]|0.448|
|[[:human genes:s:smg9|SMG9]]|0.447|
|[[:human genes:d:dad1|DAD1]]|0.446|
|[[:human genes:c:cept1|CEPT1]]|0.445|
|[[:human genes:r:rpp21|RPP21]]|0.444|
|[[:human genes:c:cycs|CYCS]]|0.442|
|[[:human genes:u:uhrf1|UHRF1]]|0.441|
|[[:human genes:s:slc25a26|SLC25A26]]|0.441|
|[[:human genes:u:urm1|URM1]]|0.44|
|[[:human genes:a:atxn10|ATXN10]]|0.439|
|[[:human genes:t:tamm41|TAMM41]]|0.437|
|[[:human genes:p:pggt1b|PGGT1B]]|0.436|
|[[:human genes:a:atp5h|ATP5H]]|0.436|
|[[:human genes:b:bcs1l|BCS1L]]|0.432|
|[[:human genes:u:ube2k|UBE2K]]|0.432|
|[[:human genes:m:mbtps2|MBTPS2]]|0.432|
|[[:human genes:h:hccs|HCCS]]|0.431|
|[[:human genes:l:lsm11|LSM11]]|0.43|
|[[:human genes:e:eif4e|EIF4E]]|0.43|
|[[:human genes:u:ubqln1|UBQLN1]]|0.429|
|[[:human genes:a:atp2a2|ATP2A2]]|0.426|
|[[:human genes:a:aars|AARS]]|0.426|
|[[:human genes:n:nae1|NAE1]]|0.425|
|[[:human genes:d:dr1|DR1]]|0.425|
|[[:human genes:a:alg9|ALG9]]|0.425|
|[[:human genes:d:diablo|DIABLO]]|0.425|
|[[:human genes:l:lsmd1|LSMD1]]|0.424|
|[[:human genes:a:atp5l|ATP5L]]|0.422|
|[[:human genes:a:atp5c1|ATP5C1]]|0.421|
|[[:human genes:v:vdac2|VDAC2]]|0.419|
|[[:human genes:t:tti2|TTI2]]|0.419|
|[[:human genes:t:timm22|TIMM22]]|0.418|
|[[:human genes:u:utp23|UTP23]]|0.418|
|[[:human genes:a:alg2|ALG2]]|0.416|
|[[:human genes:t:tle4|TLE4]]|0.414|
|[[:human genes:r:rpe|RPE]]|0.413|
|[[:human genes:e:eed|EED]]|0.413|
|[[:human genes:t:trnt1|TRNT1]]|0.412|
|[[:human genes:f:fh|FH]]|0.412|
|[[:human genes:c:cmtr1|CMTR1]]|0.411|
|[[:human genes:r:rad23b|RAD23B]]|0.411|
|[[:human genes:s:serf2|SERF2]]|0.41|
|[[:human genes:p:pelo|PELO]]|0.41|
|[[:human genes:s:slc35b1|SLC35B1]]|0.407|
|[[:human genes:c:chka|CHKA]]|0.406|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.406|
|[[:human genes:b:btaf1|BTAF1]]|0.406|
|[[:human genes:d:dpf2|DPF2]]|0.403|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.403|
|[[:human genes:d:dennd4a|DENND4A]]|0.402|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.402|
|[[:human genes:p:pdap1|PDAP1]]|0.402|
|[[:human genes:c:cdipt|CDIPT]]|0.402|
|[[:human genes:u:uba3|UBA3]]|0.401|
|[[:human genes:s:sec61b|SEC61B]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 20/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 300
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBE2G2 Expression in NALM6 Cells: 7.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>