UBE3D [The Human Chemical-Genetic Interaction Map Project]

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======= UBE3D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBE3D
  * **<color #00a2e8>Official Name</color>**: ubiquitin protein ligase E3D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=90025|90025]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z6J8|Q7Z6J8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBE3D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBE3D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612495|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. {ECO:0000269|PubMed:15749827}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF2351|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquitin-like protein conjugating enzyme binding|
|cyclin binding|
|ubiquitin conjugating enzyme binding|
|protein monoubiquitination|
|protein autoubiquitination|
|ubiquitin ligase complex|
|ubiquitin protein ligase activity|
|protein polyubiquitination|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|protein modification by small protein conjugation|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|proteolysis|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.89|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-2.56|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.54|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-2.51|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-2.28|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-2.18|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-2.14|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-2.03|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-1.92|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.86|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-1.84|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-1.83|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|-1.77|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-1.71|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.72|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.94|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.94|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.96|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.12|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.44|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|2.46|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.64|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2134
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBE3D Expression in NALM6 Cells: 4.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>