UBIAD1 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= UBIAD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBIAD1
  * **<color #00a2e8>Official Name</color>**: UbiA prenyltransferase domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29914|29914]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5Z9|Q9Y5Z9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBIAD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBIAD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611632|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein thought to be involved in cholesterol and phospholipid metabolism. Mutations in this gene are associated with Schnyder crystalline corneal dystrophy. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2- methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays a important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress. {ECO:0000269|PubMed:20953171, ECO:0000269|PubMed:23374346}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UbiA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|menaquinone biosynthetic process|
|ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate|
|vitamin K biosynthetic process|
|prenyltransferase activity|
|menaquinone metabolic process|
|vitamin K metabolic process|
|fat-soluble vitamin biosynthetic process|
|ubiquinone biosynthetic process|
|vitamin biosynthetic process|
|quinone biosynthetic process|
|ubiquinone metabolic process|
|antioxidant activity|
|ketone biosynthetic process|
|quinone metabolic process|
|fat-soluble vitamin metabolic process|
|oxidoreduction coenzyme metabolic process|
|integral component of Golgi membrane|
|cellular ketone metabolic process|
|cellular oxidant detoxification|
|cellular detoxification|
|mitochondrial membrane|
|vitamin metabolic process|
|detoxification|
|coenzyme biosynthetic process|
|cofactor biosynthetic process|
|cellular response to toxic substance|
|coenzyme metabolic process|
|cofactor metabolic process|
|response to toxic substance|
|small molecule biosynthetic process|
|endoplasmic reticulum membrane|
|endoplasmic reticulum|
|small molecule metabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.49|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-2.27|
|[[:results:exp274|Citral 50μM R06 exp274]]|-2.26|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.96|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-1.74|
|[[:results:exp453|B02 10μM R08 exp453]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 88/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|3/26|
|breast|4/33|
|central nervous system|9/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|4/21|
|liver|1/20|
|lung|16/75|
|lymphocyte|1/16|
|ovary|3/26|
|pancreas|3/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|6/24|
|soft tissue|2/9|
|thyroid|1/2|
|upper aerodigestive|3/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9686
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBIAD1 Expression in NALM6 Cells: 5.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>