UFD1L [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= UFD1L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UFD1
  * **<color #00a2e8>Official Name</color>**: ubiquitin recognition factor in ER associated degradation 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7353|7353]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92890|Q92890]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UFD1L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UFD1L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601754|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729). {ECO:0000250|UniProtKB:Q9ES53, ECO:0000269|PubMed:26471729}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UFD1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|UFD1-NPL4 complex|
|K48-linked polyubiquitin modification-dependent protein binding|
|VCP-NPL4-UFD1 AAA ATPase complex|
|negative regulation of RIG-I signaling pathway|
|negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|
|ER-associated misfolded protein catabolic process|
|endoplasmic reticulum to cytosol transport|
|regulation of RIG-I signaling pathway|
|retrograde protein transport, ER to cytosol|
|error-free translesion synthesis|
|regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|
|cellular response to misfolded protein|
|negative regulation of defense response to virus|
|protein exit from endoplasmic reticulum|
|response to misfolded protein|
|protein quality control for misfolded or incompletely synthesized proteins|
|translesion synthesis|
|negative regulation of type I interferon production|
|DNA synthesis involved in DNA repair|
|postreplication repair|
|regulation of defense response to virus|
|ATPase binding|
|ERAD pathway|
|negative regulation of response to biotic stimulus|
|thiol-dependent ubiquitin-specific protease activity|
|DNA biosynthetic process|
|negative regulation of immune effector process|
|regulation of type I interferon production|
|cellular response to topologically incorrect protein|
|response to topologically incorrect protein|
|negative regulation of defense response|
|negative regulation of multi-organism process|
|response to endoplasmic reticulum stress|
|protein-containing complex binding|
|negative regulation of cytokine production|
|protein deubiquitination|
|protein modification by small protein removal|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|signaling receptor binding|
|proteasomal protein catabolic process|
|negative regulation of response to external stimulus|
|negative regulation of immune system process|
|regulation of innate immune response|
|regulation of immune effector process|
|skeletal system development|
|negative regulation of intracellular signal transduction|
|DNA repair|
|regulation of response to biotic stimulus|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|regulation of cytokine production|
|DNA metabolic process|
|regulation of defense response|
|regulation of multi-organism process|
|cellular response to DNA damage stimulus|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|intracellular protein transport|
|response to organonitrogen compound|
|endoplasmic reticulum|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|regulation of immune response|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|proteolysis|
|organic cyclic compound biosynthetic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|regulation of immune system process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.28|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.06|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.7|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|1.8|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 602/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|26/28|
|bone|23/26|
|breast|30/33|
|central nervous system|41/56|
|cervix|2/4|
|colorectal|13/17|
|esophagus|8/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|15/21|
|liver|16/20|
|lung|61/75|
|lymphocyte|16/16|
|ovary|23/26|
|pancreas|21/24|
|peripheral nervous system|12/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|20/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|14/22|
|urinary tract|20/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 835
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UFD1L Expression in NALM6 Cells: 6.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>