UGDH [The Human Chemical-Genetic Interaction Map Project]

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======= UGDH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UGDH
  * **<color #00a2e8>Official Name</color>**: UDP-glucose 6-dehydrogenase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7358|7358]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60701|O60701]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UGDH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UGDH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603370|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UDPG MGDP dh C|
|UDPG MGDP dh|
|UDPG MGDP dh N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|UDP-glucose 6-dehydrogenase activity|
|UDP-glucuronate biosynthetic process|
|UDP-glucuronate metabolic process|
|protein hexamerization|
|nucleotide-sugar biosynthetic process|
|chondroitin sulfate biosynthetic process|
|gastrulation with mouth forming second|
|heparan sulfate proteoglycan biosynthetic process|
|chondroitin sulfate proteoglycan biosynthetic process|
|heparan sulfate proteoglycan metabolic process|
|nucleotide-sugar metabolic process|
|chondroitin sulfate metabolic process|
|NAD binding|
|chondroitin sulfate proteoglycan metabolic process|
|proteoglycan biosynthetic process|
|proteoglycan metabolic process|
|glycosaminoglycan biosynthetic process|
|mucopolysaccharide metabolic process|
|aminoglycan biosynthetic process|
|glycosaminoglycan metabolic process|
|gastrulation|
|aminoglycan metabolic process|
|sulfur compound biosynthetic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|glycoprotein biosynthetic process|
|sulfur compound metabolic process|
|glycoprotein metabolic process|
|carbohydrate metabolic process|
|protein complex oligomerization|
|nucleobase-containing small molecule metabolic process|
|embryonic morphogenesis|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|embryo development|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.68|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|1.72|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.04|
|[[:results:exp518|RK-33 8μM R08 exp518]]|2.1|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.571|
|[[:human genes:p:papss1|PAPSS1]]|0.45|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7127
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UGDH Expression in NALM6 Cells: 4.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>