UGT1A8 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= UGT1A8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/A
  * **<color #00a2e8>Official Name</color>**: N/A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: N/A
  * **<color #00a2e8>UniProt</color>**: N/A
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UGT1A8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UGT1A8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glyco tran 28 C|
|UDPGT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|flavone metabolic process|
|coumarin metabolic process|
|phenylpropanoid metabolic process|
|flavonoid glucuronidation|
|xenobiotic glucuronidation|
|flavonoid metabolic process|
|cellular glucuronidation|
|UDP-glycosyltransferase activity|
|glucuronate metabolic process|
|uronic acid metabolic process|
|fatty acid binding|
|negative regulation of fatty acid metabolic process|
|negative regulation of steroid metabolic process|
|retinoic acid binding|
|glucuronosyltransferase activity|
|steroid binding|
|enzyme inhibitor activity|
|retinoic acid metabolic process|
|secondary metabolic process|
|pigment metabolic process|
|negative regulation of lipid metabolic process|
|regulation of fatty acid metabolic process|
|negative regulation of small molecule metabolic process|
|retinoid metabolic process|
|diterpenoid metabolic process|
|regulation of steroid metabolic process|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|xenobiotic metabolic process|
|isoprenoid metabolic process|
|regulation of cellular ketone metabolic process|
|cellular response to xenobiotic stimulus|
|monosaccharide metabolic process|
|hormone metabolic process|
|steroid metabolic process|
|response to xenobiotic stimulus|
|fatty acid metabolic process|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|carbohydrate metabolic process|
|protein heterodimerization activity|
|monocarboxylic acid metabolic process|
|regulation of hormone levels|
|intracellular membrane-bounded organelle|
|negative regulation of catalytic activity|
|protein homodimerization activity|
|carboxylic acid metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxoacid metabolic process|
|endoplasmic reticulum|
|organic acid metabolic process|
|negative regulation of molecular function|
|lipid metabolic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-1.7|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11362
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UGT1A8 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>