UNC13B [The Human Chemical-Genetic Interaction Map Project]

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======= UNC13B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UNC13B
  * **<color #00a2e8>Official Name</color>**: unc-13 homolog B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10497|10497]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14795|O14795]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UNC13B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UNC13B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605836|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity- depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2|
|C1 1|
|Membr traf MHD|
|DUF1041|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of synaptic vesicle priming|
|dense core granule priming|
|ribbon synapse|
|negative regulation of synaptic plasticity|
|neuronal dense core vesicle exocytosis|
|presynaptic dense core vesicle exocytosis|
|acrosomal vesicle exocytosis|
|modulation of inhibitory postsynaptic potential|
|regulation of synaptic vesicle priming|
|positive regulation of inhibitory postsynaptic potential|
|dense core granule exocytosis|
|positive regulation of synaptic vesicle exocytosis|
|positive regulation of defense response to bacterium|
|early phagosome|
|synaptic vesicle docking|
|diacylglycerol binding|
|synaptic vesicle maturation|
|presynaptic active zone cytoplasmic component|
|regulation of short-term neuronal synaptic plasticity|
|synaptic vesicle priming|
|regulation of defense response to bacterium|
|calcium ion-regulated exocytosis of neurotransmitter|
|positive regulation of neurotransmitter secretion|
|GTP-dependent protein binding|
|acrosome reaction|
|calyx of Held|
|syntaxin-1 binding|
|innervation|
|glutamate secretion|
|synaptic transmission, glutamatergic|
|hippocampal mossy fiber to CA3 synapse|
|presynaptic active zone|
|positive regulation of neurotransmitter transport|
|vesicle docking involved in exocytosis|
|calcium-ion regulated exocytosis|
|neuromuscular junction development|
|phagosome maturation|
|acidic amino acid transport|
|terminal bouton|
|positive regulation of regulated secretory pathway|
|regulation of neuronal synaptic plasticity|
|positive regulation of nervous system process|
|vesicle docking|
|synaptic vesicle exocytosis|
|exocytic process|
|synaptic vesicle membrane|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|presynaptic membrane|
|neuromuscular junction|
|regulation of synaptic vesicle exocytosis|
|nerve development|
|dicarboxylic acid transport|
|cellular response to carbohydrate stimulus|
|acid secretion|
|cellular glucose homeostasis|
|positive regulation of exocytosis|
|neurotransmitter secretion|
|signal release from synapse|
|regulation of neurotransmitter secretion|
|phospholipid binding|
|regulation of synaptic vesicle cycle|
|synaptic vesicle cycle|
|amino acid transport|
|vesicle-mediated transport in synapse|
|regulation of nervous system process|
|response to glucose|
|single fertilization|
|regulation of neurotransmitter transport|
|response to hexose|
|response to monosaccharide|
|Rab GTPase binding|
|positive regulation of synaptic transmission|
|regulation of regulated secretory pathway|
|signal release|
|fertilization|
|organelle localization by membrane tethering|
|response to carbohydrate|
|neurotransmitter transport|
|membrane docking|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of synaptic plasticity|
|calmodulin binding|
|regulation of exocytosis|
|developmental maturation|
|positive regulation of protein complex assembly|
|synapse organization|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|carboxylic acid transport|
|organic acid transport|
|vesicle organization|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|positive regulation of response to biotic stimulus|
|positive regulation of secretion by cell|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|positive regulation of protein transport|
|regulation of membrane potential|
|positive regulation of secretion|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of protein complex assembly|
|organic anion transport|
|positive regulation of establishment of protein localization|
|synaptic signaling|
|regulation of protein secretion|
|positive regulation of defense response|
|regulation of peptide secretion|
|positive regulation of multi-organism process|
|positive regulation of cellular component biogenesis|
|regulation of response to biotic stimulus|
|cell junction|
|regulation of vesicle-mediated transport|
|organelle localization|
|anion transport|
|regulation of system process|
|positive regulation of response to external stimulus|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|regulated exocytosis|
|regulation of protein transport|
|calcium ion binding|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|regulation of multi-organism process|
|exocytosis|
|regulation of secretion|
|sexual reproduction|
|cellular protein-containing complex assembly|
|cellular homeostasis|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|Golgi apparatus|
|positive regulation of transport|
|multi-organism reproductive process|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|cellular response to oxygen-containing compound|
|regulation of response to external stimulus|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|positive regulation of cellular component organization|
|ion transport|
|reproductive process|
|reproduction|
|regulation of response to stress|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-1.73|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5752
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UNC13B Expression in NALM6 Cells: 5.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>