UNK [The Human Chemical-Genetic Interaction Map Project]

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======= UNK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UNK
  * **<color #00a2e8>Official Name</color>**: unk zinc finger
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=85451|85451]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9C0B0|Q9C0B0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UNK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UNK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616375|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280). {ECO:0000269|PubMed:25737280}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mRNA CDS binding|
|polysome binding|
|negative regulation of cytoplasmic translation|
|regulation of cytoplasmic translation|
|polysome|
|neuron migration|
|negative regulation of translation|
|negative regulation of cellular amide metabolic process|
|regulation of translation|
|in utero embryonic development|
|regulation of cellular amide metabolic process|
|cell morphogenesis involved in neuron differentiation|
|posttranscriptional regulation of gene expression|
|cell morphogenesis involved in differentiation|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|cell migration|
|embryo development|
|neuron differentiation|
|negative regulation of cellular protein metabolic process|
|localization of cell|
|cell motility|
|negative regulation of protein metabolic process|
|locomotion|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-2.25|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-2.1|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.96|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.89|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.77|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-1.72|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.85|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.07|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|2.21|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|2.3|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.6|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7560
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UNK Expression in NALM6 Cells: 5.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>