UQCRC1 [The Human Chemical-Genetic Interaction Map Project]

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======= UQCRC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UQCRC1
  * **<color #00a2e8>Official Name</color>**: ubiquinol-cytochrome c reductase core protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7384|7384]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31930|P31930]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UQCRC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UQCRC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191328|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M16|
|Peptidase M16 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquinol-cytochrome-c reductase activity|
|mitochondrial respiratory chain complex III|
|mitochondrial electron transport, ubiquinol to cytochrome c|
|mitochondrial respirasome|
|response to activity|
|aerobic respiration|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|respiratory electron transport chain|
|response to alkaloid|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|protein-containing complex binding|
|ubiquitin protein ligase binding|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|oxidation-reduction process|
|response to organonitrogen compound|
|response to nitrogen compound|
|mitochondrion|
|phosphorylation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.79|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.82|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.83|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.9|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.43|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.83|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|3.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:uqcrc2|UQCRC2]]|0.507|
|[[:human genes:b:bcs1l|BCS1L]]|0.495|
|[[:human genes:t:tufm|TUFM]]|0.479|
|[[:human genes:g:gfm1|GFM1]]|0.477|
|[[:human genes:m:mrps21|MRPS21]]|0.476|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.472|
|[[:human genes:m:mrpl21|MRPL21]]|0.467|
|[[:human genes:h:hars2|HARS2]]|0.466|
|[[:human genes:c:cox16|COX16]]|0.458|
|[[:human genes:n:ndufa2|NDUFA2]]|0.445|
|[[:human genes:u:uqcrfs1|UQCRFS1]]|0.445|
|[[:human genes:s:sars2|SARS2]]|0.443|
|[[:human genes:f:fastkd5|FASTKD5]]|0.443|
|[[:human genes:d:dap3|DAP3]]|0.442|
|[[:human genes:n:ndufb4|NDUFB4]]|0.439|
|[[:human genes:v:vars2|VARS2]]|0.437|
|[[:human genes:m:mrpl45|MRPL45]]|0.432|
|[[:human genes:t:trub2|TRUB2]]|0.425|
|[[:human genes:n:ndufb11|NDUFB11]]|0.424|
|[[:human genes:c:cox7b|COX7B]]|0.423|
|[[:human genes:s:selrc1|SELRC1]]|0.422|
|[[:human genes:m:mrps14|MRPS14]]|0.421|
|[[:human genes:m:mrpl43|MRPL43]]|0.417|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.417|
|[[:human genes:u:uqcr10|UQCR10]]|0.416|
|[[:human genes:n:nars2|NARS2]]|0.414|
|[[:human genes:m:mrps9|MRPS9]]|0.412|
|[[:human genes:r:rars2|RARS2]]|0.411|
|[[:human genes:c:c10orf2|C10orf2]]|0.41|
|[[:human genes:m:mrps28|MRPS28]]|0.406|
|[[:human genes:m:mrps2|MRPS2]]|0.405|
|[[:human genes:m:mrps6|MRPS6]]|0.403|
|[[:human genes:n:ndufv1|NDUFV1]]|0.402|
|[[:human genes:s:sco2|SCO2]]|0.401|
|[[:human genes:m:mrps16|MRPS16]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 32/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|1/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|0/20|
|lung|5/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 824
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UQCRC1 Expression in NALM6 Cells: 7.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>