UQCRH [The Human Chemical-Genetic Interaction Map Project]

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======= UQCRH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UQCRH
  * **<color #00a2e8>Official Name</color>**: ubiquinol-cytochrome c reductase hinge protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7388|7388]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07919|P07919]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UQCRH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UQCRH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613844|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UCR hinge|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquinol-cytochrome-c reductase activity|
|mitochondrial respiratory chain complex III|
|mitochondrial electron transport, ubiquinol to cytochrome c|
|mitochondrial respirasome|
|aerobic respiration|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|oxidation-reduction process|
|mitochondrion|
|phosphorylation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.78|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|1.99|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|2.52|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.492|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.492|
|[[:human genes:h:hinfp|HINFP]]|0.491|
|[[:human genes:c:chd4|CHD4]]|0.485|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.481|
|[[:human genes:p:pola1|POLA1]]|0.473|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.468|
|[[:human genes:p:polr2d|POLR2D]]|0.468|
|[[:human genes:d:dtl|DTL]]|0.463|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.461|
|[[:human genes:c:cbwd3|CBWD3]]|0.461|
|[[:human genes:r:rad51|RAD51]]|0.457|
|[[:human genes:d:ddtl|DDTL]]|0.455|
|[[:human genes:m:mt1e|MT1E]]|0.453|
|[[:human genes:r:rpl35|RPL35]]|0.453|
|[[:human genes:v:vasn|VASN]]|0.452|
|[[:human genes:f:fam160a1|FAM160A1]]|0.449|
|[[:human genes:s:slc4a1|SLC4A1]]|0.446|
|[[:human genes:c:cbwd5|CBWD5]]|0.444|
|[[:human genes:p:pan3|PAN3]]|0.443|
|[[:human genes:s:smg7|SMG7]]|0.44|
|[[:human genes:s:supt6h|SUPT6H]]|0.439|
|[[:human genes:p:paf1|PAF1]]|0.438|
|[[:human genes:n:nop16|NOP16]]|0.438|
|[[:human genes:p:pan2|PAN2]]|0.437|
|[[:human genes:c:copb1|COPB1]]|0.437|
|[[:human genes:n:npipb5|NPIPB5]]|0.437|
|[[:human genes:h:hivep3|HIVEP3]]|0.437|
|[[:human genes:c:ccna2|CCNA2]]|0.434|
|[[:human genes:p:psmc4|PSMC4]]|0.434|
|[[:human genes:p:polr2j3|POLR2J3]]|0.432|
|[[:human genes:p:psma6|PSMA6]]|0.43|
|[[:human genes:o:orc1|ORC1]]|0.428|
|[[:human genes:r:rrp7a|RRP7A]]|0.428|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.427|
|[[:human genes:c:cdca3|CDCA3]]|0.424|
|[[:human genes:m:mdm2|MDM2]]|0.423|
|[[:human genes:p:plk1|PLK1]]|0.422|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.422|
|[[:human genes:p:pole|POLE]]|0.422|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.421|
|[[:human genes:p:pwp2|PWP2]]|0.421|
|[[:human genes:r:rps2|RPS2]]|0.42|
|[[:human genes:t:tspy1|TSPY1]]|0.417|
|[[:human genes:s:sf3a1|SF3A1]]|0.416|
|[[:human genes:k:kctd17|KCTD17]]|0.414|
|[[:human genes:t:traip|TRAIP]]|0.414|
|[[:human genes:c:cbwd6|CBWD6]]|0.413|
|[[:human genes:i:igfn1|IGFN1]]|0.412|
|[[:human genes:t:tfip11|TFIP11]]|0.412|
|[[:human genes:n:nupl1|NUPL1]]|0.411|
|[[:human genes:p:psmd3|PSMD3]]|0.411|
|[[:human genes:h:hap1|HAP1]]|0.411|
|[[:human genes:o:orc6|ORC6]]|0.41|
|[[:human genes:p:psmc2|PSMC2]]|0.41|
|[[:human genes:s:stil|STIL]]|0.41|
|[[:human genes:n:ndc80|NDC80]]|0.409|
|[[:human genes:a:arcn1|ARCN1]]|0.409|
|[[:human genes:r:riok2|RIOK2]]|0.409|
|[[:human genes:l:lad1|LAD1]]|0.408|
|[[:human genes:s:ssh2|SSH2]]|0.408|
|[[:human genes:p:psmd14|PSMD14]]|0.407|
|[[:human genes:t:tceb3c|TCEB3C]]|0.406|
|[[:human genes:c:col2a1|COL2A1]]|0.406|
|[[:human genes:a:atxn1|ATXN1]]|0.405|
|[[:human genes:s:supt5h|SUPT5H]]|0.404|
|[[:human genes:t:tspy8|TSPY8]]|0.403|
|[[:human genes:n:npipa7|NPIPA7]]|0.402|
|[[:human genes:n:npipa8|NPIPA8]]|0.402|
|[[:human genes:r:rps5|RPS5]]|0.402|
|[[:human genes:r:rad21|RAD21]]|0.401|
|[[:human genes:u:upf1|UPF1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 738/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1706
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UQCRH Expression in NALM6 Cells: 6.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>