URB2 [The Human Chemical-Genetic Interaction Map Project]

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======= URB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: URB2
  * **<color #00a2e8>Official Name</color>**: URB2 ribosome biogenesis homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9816|9816]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14146|Q14146]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=URB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20URB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619372|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Urb2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|aggresome|
|midbody|
|ribosome biogenesis|
|ribonucleoprotein complex biogenesis|
|nucleolus|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|1.74|
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.88|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c14orf93|C14orf93]]|0.431|
|[[:human genes:p:pwp2|PWP2]]|0.426|
|[[:human genes:s:snrpa1|SNRPA1]]|0.426|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.422|
|[[:human genes:p:pola2|POLA2]]|0.418|
|[[:human genes:p:psmd6|PSMD6]]|0.413|
|[[:human genes:c:cope|COPE]]|0.411|
|[[:human genes:p:psmd3|PSMD3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 41/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|2/28|
|bone|2/26|
|breast|0/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|1/1|
|gastric|1/16|
|kidney|1/21|
|liver|1/20|
|lung|8/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|2/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 178
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='URB2 Expression in NALM6 Cells: 6.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>