URI1 [The Human Chemical-Genetic Interaction Map Project]

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======= URI1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: URI1
  * **<color #00a2e8>Official Name</color>**: URI1 prefoldin like chaperone
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8725|8725]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94763|O94763]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=URI1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20URI1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603494|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Prefoldin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatase inhibitor activity|
|RNA polymerase II complex binding|
|protein phosphatase inhibitor activity|
|phosphoprotein binding|
|negative regulation of phosphoprotein phosphatase activity|
|negative regulation of protein dephosphorylation|
|negative regulation of intrinsic apoptotic signaling pathway|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|regulation of phosphoprotein phosphatase activity|
|regulation of protein dephosphorylation|
|regulation of intrinsic apoptotic signaling pathway|
|regulation of phosphatase activity|
|cellular response to steroid hormone stimulus|
|regulation of dephosphorylation|
|negative regulation of apoptotic signaling pathway|
|transcription corepressor activity|
|response to virus|
|response to steroid hormone|
|chromatin binding|
|regulation of apoptotic signaling pathway|
|regulation of cell growth|
|dendrite|
|negative regulation of hydrolase activity|
|cellular response to growth factor stimulus|
|negative regulation of intracellular signal transduction|
|cellular response to lipid|
|response to growth factor|
|cellular response to organic cyclic compound|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|cellular response to hormone stimulus|
|regulation of growth|
|negative regulation of catalytic activity|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|response to organic cyclic compound|
|negative regulation of cell death|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|regulation of cell death|
|negative regulation of gene expression|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-3.13|
|[[:results:exp392|PT-1 25μM R07 exp392]]|-2.23|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-2.06|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.99|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-1.93|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.92|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.8|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.74|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.74|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.73|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.8|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.86|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|1.94|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|2.07|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 546/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|24/28|
|blood|22/28|
|bone|22/25|
|breast|27/33|
|central nervous system|37/56|
|cervix|4/4|
|colorectal|11/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|12/15|
|kidney|11/21|
|liver|12/20|
|lung|57/75|
|lymphocyte|11/14|
|ovary|23/26|
|pancreas|21/24|
|peripheral nervous system|13/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|18/24|
|soft tissue|2/7|
|thyroid|1/2|
|upper aerodigestive|18/22|
|urinary tract|23/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3727
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='URI1 Expression in NALM6 Cells: 6.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>