USF2 [The Human Chemical-Genetic Interaction Map Project]

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======= USF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: USF2
  * **<color #00a2e8>Official Name</color>**: upstream transcription factor 2, c-fos interacting
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7392|7392]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15853|Q15853]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=USF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20USF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600390|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the basic helix-loop-helix leucine zipper family of transcription factors. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs and is involved in regulating multiple cellular processes. [provided by RefSeq, Mar 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of transcription from RNA polymerase II promoter by glucose|
|regulation of transcription from RNA polymerase II promoter by glucose|
|late viral transcription|
|positive regulation of transcription by glucose|
|carbon catabolite activation of transcription from RNA polymerase II promoter|
|carbon catabolite regulation of transcription from RNA polymerase II promoter|
|regulation of transcription by glucose|
|carbon catabolite regulation of transcription|
|carbon catabolite activation of transcription|
|bHLH transcription factor binding|
|lactation|
|cellular response to nutrient|
|body fluid secretion|
|viral transcription|
|mammary gland development|
|viral gene expression|
|lipid homeostasis|
|response to nutrient|
|cellular response to nutrient levels|
|cellular response to extracellular stimulus|
|cellular response to external stimulus|
|gland development|
|sequence-specific DNA binding|
|transcription by RNA polymerase II|
|protein heterodimerization activity|
|regulation of body fluid levels|
|response to nutrient levels|
|response to extracellular stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|intracellular membrane-bounded organelle|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|protein homodimerization activity|
|nucleobase-containing compound biosynthetic process|
|chemical homeostasis|
|secretion|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|organic cyclic compound biosynthetic process|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.79|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.78|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.71|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.71|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.77|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.83|
|[[:results:exp132|Metformin 40μM R03 exp132]]|1.9|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.93|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|2.17|
|[[:results:exp504|MK2206 4μM R08 exp504]]|3.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5722
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='USF2 Expression in NALM6 Cells: 6.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>