USO1 [The Human Chemical-Genetic Interaction Map Project]

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======= USO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: USO1
  * **<color #00a2e8>Official Name</color>**: USO1 vesicle transport factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8615|8615]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60763|O60763]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=USO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20USO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603344|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. {ECO:0000250|UniProtKB:P41542}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Golgi vesicle docking|
|vesicle fusion with Golgi apparatus|
|secretory granule localization|
|transcytosis|
|Golgi stack|
|ER to Golgi transport vesicle membrane|
|COPII vesicle coating|
|vesicle docking|
|vesicle targeting, rough ER to cis-Golgi|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|vesicle fusion|
|regulation of cellular response to insulin stimulus|
|Golgi vesicle budding|
|organelle membrane fusion|
|vesicle targeting|
|transport vesicle|
|vesicle budding from membrane|
|organelle fusion|
|membrane fusion|
|Golgi organization|
|fibrillar center|
|organelle localization by membrane tethering|
|establishment of vesicle localization|
|membrane docking|
|vesicle localization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|vesicle organization|
|cadherin binding|
|small GTPase mediated signal transduction|
|establishment of organelle localization|
|Golgi vesicle transport|
|endomembrane system organization|
|organelle localization|
|Golgi membrane|
|perinuclear region of cytoplasm|
|membrane organization|
|Golgi apparatus|
|intracellular protein transport|
|endoplasmic reticulum|
|RNA binding|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-3.52|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|-3.29|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-3.19|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-3.03|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.44|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.99|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.97|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.97|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.96|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-1.91|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.86|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.78|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.78|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.77|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-1.73|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-1.72|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-1.71|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.71|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.72|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.77|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.79|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.8|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.84|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.96|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.96|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.11|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.16|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.5|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.79|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|3.15|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|3.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dpagt1|DPAGT1]]|0.535|
|[[:human genes:a:alg5|ALG5]]|0.5|
|[[:human genes:m:mbtps2|MBTPS2]]|0.493|
|[[:human genes:a:alg6|ALG6]]|0.49|
|[[:human genes:g:gfpt1|GFPT1]]|0.476|
|[[:human genes:s:srd5a3|SRD5A3]]|0.467|
|[[:human genes:s:sec16a|SEC16A]]|0.464|
|[[:human genes:m:mbtps1|MBTPS1]]|0.463|
|[[:human genes:d:dolk|DOLK]]|0.459|
|[[:human genes:a:alg1|ALG1]]|0.457|
|[[:human genes:a:atxn10|ATXN10]]|0.456|
|[[:human genes:t:tmed10|TMED10]]|0.451|
|[[:human genes:k:kiaa1432|KIAA1432]]|0.444|
|[[:human genes:p:pgm3|PGM3]]|0.443|
|[[:human genes:a:alg8|ALG8]]|0.442|
|[[:human genes:d:dhrsx|DHRSX]]|0.437|
|[[:human genes:u:uap1|UAP1]]|0.434|
|[[:human genes:e:eny2|ENY2]]|0.43|
|[[:human genes:c:cept1|CEPT1]]|0.43|
|[[:human genes:c:chka|CHKA]]|0.429|
|[[:human genes:a:alg3|ALG3]]|0.428|
|[[:human genes:m:mrps6|MRPS6]]|0.425|
|[[:human genes:t:thg1l|THG1L]]|0.425|
|[[:human genes:s:sec31a|SEC31A]]|0.424|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.405|
|[[:human genes:c:cog2|COG2]]|0.403|
|[[:human genes:f:flvcr1|FLVCR1]]|0.403|
|[[:human genes:t:timm13|TIMM13]]|0.403|
|[[:human genes:v:vezt|VEZT]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7773
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='USO1 Expression in NALM6 Cells: 6.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>