USP17L2 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= USP17L2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: USP17L2
  * **<color #00a2e8>Official Name</color>**: ubiquitin specific peptidase 17 like family member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=377630|377630]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6R6M4|Q6R6M4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=USP17L2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20USP17L2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610186|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors DDX58 and IFIH1 stimulates the cellular response to viral infection. {ECO:0000269|PubMed:14699124, ECO:0000269|PubMed:17109758, ECO:0000269|PubMed:19188362, ECO:0000269|PubMed:20147298, ECO:0000269|PubMed:20228808, ECO:0000269|PubMed:20368735, ECO:0000269|PubMed:20388806, ECO:0000269|PubMed:21239494, ECO:0000269|PubMed:21448158}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CAAX-box protein processing|
|CAAX-box protein maturation|
|positive regulation of MDA-5 signaling pathway|
|negative regulation of histone deacetylation|
|negative regulation of protein targeting to membrane|
|regulation of MDA-5 signaling pathway|
|positive regulation of RIG-I signaling pathway|
|regulation of RIG-I signaling pathway|
|regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|
|regulation of histone deacetylation|
|regulation of ruffle assembly|
|negative regulation of protein localization to membrane|
|protein K63-linked deubiquitination|
|protein K48-linked deubiquitination|
|negative regulation of protein processing|
|negative regulation of protein maturation|
|regulation of defense response to virus by host|
|regulation of protein targeting to membrane|
|negative regulation of histone modification|
|negative regulation of intracellular protein transport|
|regulation of protein deacetylation|
|negative regulation of GTPase activity|
|thiol-dependent ubiquitinyl hydrolase activity|
|negative regulation of intracellular transport|
|negative regulation of chromatin organization|
|regulation of protein processing|
|regulation of protein maturation|
|regulation of defense response to virus|
|regulation of protein targeting|
|cysteine-type endopeptidase activity|
|thiol-dependent ubiquitin-specific protease activity|
|negative regulation of cellular protein localization|
|negative regulation of chromosome organization|
|regulation of histone modification|
|mitotic cell cycle checkpoint|
|protein processing|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|regulation of chromatin organization|
|regulation of protein localization to membrane|
|cell cycle checkpoint|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|positive regulation of immune effector process|
|protein maturation|
|regulation of intracellular protein transport|
|protein deubiquitination|
|protein modification by small protein removal|
|negative regulation of mitotic cell cycle|
|positive regulation of innate immune response|
|regulation of chromosome organization|
|regulation of intracellular transport|
|negative regulation of proteolysis|
|positive regulation of response to biotic stimulus|
|negative regulation of organelle organization|
|positive regulation of GTPase activity|
|positive regulation of cytokine production|
|regulation of innate immune response|
|negative regulation of hydrolase activity|
|regulation of immune effector process|
|positive regulation of defense response|
|regulation of GTPase activity|
|negative regulation of transport|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|regulation of cellular protein localization|
|modification-dependent macromolecule catabolic process|
|negative regulation of cell cycle|
|proteolysis involved in cellular protein catabolic process|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|positive regulation of response to external stimulus|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|protein catabolic process|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cytokine production|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of cell projection organization|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of defense response|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|regulation of cell migration|
|positive regulation of immune response|
|cellular macromolecule catabolic process|
|regulation of cell motility|
|regulation of cellular localization|
|apoptotic process|
|endoplasmic reticulum membrane|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|regulation of cellular component movement|
|cell cycle process|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|cell death|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|regulation of cell cycle|
|proteolysis|
|regulation of hydrolase activity|
|regulation of organelle organization|
|cell cycle|
|positive regulation of catalytic activity|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-2.15|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-1.86|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.83|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.76|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.72|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.567|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2751
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='USP17L2 Expression in NALM6 Cells: -3.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>