USP44 [The Human Chemical-Genetic Interaction Map Project]

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======= USP44 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: USP44
  * **<color #00a2e8>Official Name</color>**: ubiquitin specific peptidase 44
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84101|84101]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H0E7|Q9H0E7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=USP44&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20USP44|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610993|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a protease that functions as a deubiquitinating enzyme. The encoded protein is thought to help regulate the spindle assembly checkpoint by preventing early anaphase onset. This protein specifically deubiquitinates CDC20, which stabilizes the anaphase promoting complex/cyclosome. [provided by RefSeq, Dec 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination. {ECO:0000269|PubMed:17443180, ECO:0000269|PubMed:22681888}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-UBP|
|UCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of ubiquitin protein ligase activity|
|regulation of mitotic spindle checkpoint|
|regulation of spindle checkpoint|
|regulation of mitotic cell cycle spindle assembly checkpoint|
|negative regulation of ubiquitin-protein transferase activity|
|regulation of ubiquitin protein ligase activity|
|regulation of cell cycle checkpoint|
|regulation of mitotic metaphase/anaphase transition|
|regulation of ubiquitin-protein transferase activity|
|regulation of metaphase/anaphase transition of cell cycle|
|thiol-dependent ubiquitinyl hydrolase activity|
|regulation of mitotic sister chromatid separation|
|regulation of chromosome separation|
|regulation of mitotic sister chromatid segregation|
|negative regulation of protein ubiquitination|
|regulation of sister chromatid segregation|
|negative regulation of protein modification by small protein conjugation or removal|
|regulation of chromosome segregation|
|thiol-dependent ubiquitin-specific protease activity|
|regulation of mitotic nuclear division|
|regulation of nuclear division|
|regulation of protein ubiquitination|
|regulation of protein modification by small protein conjugation or removal|
|chromosome segregation|
|negative regulation of transferase activity|
|protein deubiquitination|
|protein modification by small protein removal|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|regulation of chromosome organization|
|proteasomal protein catabolic process|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|cell division|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|negative regulation of protein modification process|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|protein catabolic process|
|regulation of cell cycle process|
|negative regulation of catalytic activity|
|zinc ion binding|
|cellular macromolecule catabolic process|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|proteolysis|
|regulation of organelle organization|
|cell cycle|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4986
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='USP44 Expression in NALM6 Cells: -1.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>