USP51 [The Human Chemical-Genetic Interaction Map Project]

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======= USP51 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: USP51
  * **<color #00a2e8>Official Name</color>**: ubiquitin specific peptidase 51
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=158880|158880]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q70EK9|Q70EK9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=USP51&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20USP51|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs) (PubMed:27083998). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin (PubMed:27083998). {ECO:0000269|PubMed:27083998}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-UBP|
|UCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone deubiquitination|
|regulation of double-strand break repair via nonhomologous end joining|
|regulation of double-strand break repair via homologous recombination|
|regulation of double-strand break repair|
|regulation of DNA recombination|
|thiol-dependent ubiquitin-specific protease activity|
|chromosome|
|regulation of DNA repair|
|histone binding|
|regulation of response to DNA damage stimulus|
|protein deubiquitination|
|protein modification by small protein removal|
|regulation of DNA metabolic process|
|histone modification|
|covalent chromatin modification|
|chromatin binding|
|DNA repair|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|chromatin organization|
|regulation of cellular response to stress|
|DNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|zinc ion binding|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|chromosome organization|
|regulation of cell cycle|
|proteolysis|
|regulation of response to stress|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.78|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.73|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-1.71|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|1.75|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|1.87|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.9|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|2|
|[[:results:exp303|39°C R06 exp303]]|2.25|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|2.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9004
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.5 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='USP51 Expression in NALM6 Cells: 1.5'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>