VAMP2 [The Human Chemical-Genetic Interaction Map Project]

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======= VAMP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VAMP2
  * **<color #00a2e8>Official Name</color>**: vesicle associated membrane protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6844|6844]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P63027|P63027]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VAMP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VAMP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/185881|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. {ECO:0000250|UniProtKB:P63045}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Synaptobrevin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex|
|eosinophil degranulation|
|eosinophil activation|
|clathrin-sculpted glutamate transport vesicle membrane|
|eosinophil activation involved in immune response|
|mucus secretion|
|synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex|
|eosinophil mediated immunity|
|synaptobrevin 2-SNAP-25-syntaxin-1a complex|
|clathrin-sculpted monoamine transport vesicle membrane|
|natural killer cell degranulation|
|regulation of histamine secretion by mast cell|
|clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane|
|zymogen granule membrane|
|regulation of delayed rectifier potassium channel activity|
|neuron projection terminus|
|secretion by tissue|
|natural killer cell activation involved in immune response|
|natural killer cell mediated cytotoxicity|
|syntaxin-1 binding|
|natural killer cell mediated immunity|
|glutamate secretion|
|Golgi to plasma membrane protein transport|
|regulation of mast cell degranulation|
|regulation of mast cell activation involved in immune response|
|calcium-ion regulated exocytosis|
|leukocyte mediated cytotoxicity|
|regulation of mast cell activation|
|acidic amino acid transport|
|long-term synaptic potentiation|
|SNARE complex|
|regulation of leukocyte degranulation|
|establishment of protein localization to plasma membrane|
|clathrin-coated vesicle membrane|
|syntaxin binding|
|regulation of potassium ion transmembrane transporter activity|
|protein self-association|
|natural killer cell activation|
|clathrin-coated vesicle|
|regulation of myeloid leukocyte mediated immunity|
|Golgi to plasma membrane transport|
|calcium-dependent protein binding|
|synaptic vesicle exocytosis|
|SNARE binding|
|synaptic vesicle membrane|
|carbohydrate derivative transport|
|body fluid secretion|
|dicarboxylic acid transport|
|acid secretion|
|regulation of potassium ion transmembrane transport|
|voltage-gated potassium channel complex|
|secretory granule|
|cell killing|
|vesicle-mediated transport to the plasma membrane|
|regulation of potassium ion transport|
|secretory granule membrane|
|signal release from synapse|
|neurotransmitter secretion|
|post-Golgi vesicle-mediated transport|
|phospholipid binding|
|lymphocyte activation involved in immune response|
|synaptic vesicle cycle|
|amino acid transport|
|synaptic vesicle|
|vesicle-mediated transport in synapse|
|membrane fusion|
|response to glucose|
|vesicle|
|regulation of neurotransmitter transport|
|response to hexose|
|response to monosaccharide|
|positive regulation of synaptic transmission|
|positive regulation of intracellular protein transport|
|cellular response to insulin stimulus|
|regulation of regulated secretory pathway|
|signal release|
|trans-Golgi network|
|regulation of cation channel activity|
|response to carbohydrate|
|neurotransmitter transport|
|protein localization to plasma membrane|
|regulation of synaptic plasticity|
|calmodulin binding|
|regulation of leukocyte mediated immunity|
|positive regulation of intracellular transport|
|positive regulation of immune effector process|
|regulation of exocytosis|
|response to insulin|
|protein localization to cell periphery|
|regulation of intracellular protein transport|
|cytoplasmic vesicle|
|regulation of ion transmembrane transporter activity|
|establishment of protein localization to membrane|
|regulation of transmembrane transporter activity|
|lymphocyte mediated immunity|
|cellular response to peptide hormone stimulus|
|regulation of hormone secretion|
|synapse|
|regulation of transporter activity|
|carboxylic acid transport|
|organic acid transport|
|neuron projection|
|positive regulation of cellular protein localization|
|cellular response to peptide|
|regulation of cation transmembrane transport|
|regulation of inflammatory response|
|regulation of intracellular transport|
|regulation of neurotransmitter levels|
|Golgi vesicle transport|
|lymphocyte activation|
|regulation of metal ion transport|
|response to peptide hormone|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|positive regulation of protein transport|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|organic anion transport|
|positive regulation of establishment of protein localization|
|synaptic signaling|
|regulation of immune effector process|
|response to peptide|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of body fluid levels|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of hormone levels|
|regulation of cellular protein localization|
|cell junction|
|regulation of vesicle-mediated transport|
|regulation of transmembrane transport|
|anion transport|
|myeloid leukocyte activation|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|cellular response to hormone stimulus|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|cellular response to nitrogen compound|
|intracellular membrane-bounded organelle|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|regulated exocytosis|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|innate immune response|
|leukocyte mediated immunity|
|exocytosis|
|regulation of secretion|
|membrane organization|
|response to hormone|
|regulation of cellular localization|
|leukocyte activation|
|defense response to other organism|
|positive regulation of transport|
|response to organonitrogen compound|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|regulation of response to external stimulus|
|cell-cell signaling|
|secretion|
|regulation of immune response|
|positive regulation of immune system process|
|cellular response to endogenous stimulus|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|ion transport|
|integral component of plasma membrane|
|response to endogenous stimulus|
|regulation of response to stress|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of immune system process|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.93|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8869
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VAMP2 Expression in NALM6 Cells: 5.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>