VARS [The Human Chemical-Genetic Interaction Map Project]

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======= VARS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VARS1
  * **<color #00a2e8>Official Name</color>**: valyl-tRNA synthetase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7407|7407]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P26640|P26640]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VARS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VARS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/192150|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GST N|
|Anticodon 1|
|tRNA-synt 1|
|GST C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|valyl-tRNA aminoacylation|
|valine-tRNA ligase activity|
|aminoacyl-tRNA metabolism involved in translational fidelity|
|aminoacyl-tRNA editing activity|
|regulation of translational fidelity|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|tRNA metabolic process|
|cellular amino acid metabolic process|
|translation|
|peptide biosynthetic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|-2.16|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-2.04|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-1.86|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 677/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|25/28|
|bone|22/26|
|breast|27/33|
|central nervous system|52/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|70/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|23/24|
|peripheral nervous system|12/16|
|plasma cell|14/15|
|prostate|0/1|
|skin|22/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 77
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VARS Expression in NALM6 Cells: 7.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>