VCL [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= VCL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VCL
  * **<color #00a2e8>Official Name</color>**: vinculin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7414|7414]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P18206|P18206]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VCL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VCL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/193065|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Vinculin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell-substrate junction|
|alpha-catenin binding|
|dystroglycan binding|
|fascia adherens|
|epithelial cell-cell adhesion|
|costamere|
|protein localization to cell surface|
|podosome|
|lamellipodium assembly|
|axon extension|
|adherens junction assembly|
|lamellipodium organization|
|platelet aggregation|
|apical junction assembly|
|extracellular vesicle|
|homotypic cell-cell adhesion|
|neuron projection extension|
|specific granule lumen|
|adherens junction|
|beta-catenin binding|
|adherens junction organization|
|developmental cell growth|
|cell growth|
|sarcolemma|
|cell-cell junction assembly|
|cell-cell adherens junction|
|developmental growth involved in morphogenesis|
|secretory granule lumen|
|ficolin-1-rich granule lumen|
|cell-matrix adhesion|
|platelet degranulation|
|platelet activation|
|cell-cell junction organization|
|cell junction assembly|
|cell-cell junction|
|cell-substrate adhesion|
|structural molecule activity|
|cell junction organization|
|muscle contraction|
|negative regulation of cell migration|
|actin binding|
|negative regulation of cell motility|
|ubiquitin protein ligase binding|
|blood coagulation|
|coagulation|
|hemostasis|
|muscle system process|
|negative regulation of cellular component movement|
|cadherin binding|
|negative regulation of locomotion|
|cytoskeleton|
|axonogenesis|
|developmental growth|
|growth|
|axon development|
|focal adhesion|
|cell morphogenesis involved in neuron differentiation|
|morphogenesis of an epithelium|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|wound healing|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|neutrophil degranulation|
|cell projection morphogenesis|
|neutrophil activation involved in immune response|
|regulation of body fluid levels|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|cell-cell adhesion|
|leukocyte degranulation|
|cell part morphogenesis|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|response to wounding|
|myeloid leukocyte activation|
|protein-containing complex|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|neuron projection development|
|regulated exocytosis|
|cell morphogenesis|
|leukocyte mediated immunity|
|exocytosis|
|neuron development|
|cellular component morphogenesis|
|regulation of cell migration|
|regulation of cell motility|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|neuron differentiation|
|export from cell|
|cell activation|
|immune effector process|
|epithelium development|
|plasma membrane bounded cell projection organization|
|secretion|
|cell projection organization|
|generation of neurons|
|cellular protein localization|
|cellular macromolecule localization|
|neurogenesis|
|cell development|
|tissue development|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6677
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VCL Expression in NALM6 Cells: 6.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>