VDAC1 [The Human Chemical-Genetic Interaction Map Project]

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======= VDAC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VDAC1
  * **<color #00a2e8>Official Name</color>**: voltage dependent anion channel 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7416|7416]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P21796|P21796]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VDAC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VDAC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604492|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). {ECO:0000269|PubMed:11845315, ECO:0000269|PubMed:15033708, ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:20230784, ECO:0000269|PubMed:25296756, ECO:0000269|PubMed:8420959}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Porin 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial permeability transition pore complex|
|porin activity|
|voltage-gated anion channel activity|
|neuron-neuron synaptic transmission|
|pore complex|
|mitochondrial calcium ion transmembrane transport|
|behavioral fear response|
|behavioral defense response|
|fear response|
|regulation of autophagy of mitochondrion|
|mitochondrial nucleoid|
|negative regulation of reactive oxygen species metabolic process|
|multicellular organismal response to stress|
|pyruvate metabolic process|
|synaptic vesicle|
|ion channel binding|
|learning|
|inorganic anion transport|
|macroautophagy|
|mitochondrial outer membrane|
|regulation of reactive oxygen species metabolic process|
|regulation of mitochondrion organization|
|calcium ion transmembrane transport|
|membrane raft|
|calcium ion transport|
|learning or memory|
|process utilizing autophagic mechanism|
|autophagy|
|protein-containing complex binding|
|anion transmembrane transport|
|divalent metal ion transport|
|cognition|
|divalent inorganic cation transport|
|regulation of autophagy|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|synaptic signaling|
|protein kinase binding|
|monocarboxylic acid metabolic process|
|inorganic cation transmembrane transport|
|behavior|
|anion transport|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|epithelial cell differentiation|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|cation transport|
|regulation of cellular catabolic process|
|carboxylic acid metabolic process|
|apoptotic process|
|ion transmembrane transport|
|regulation of catabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|programmed cell death|
|identical protein binding|
|cell death|
|epithelium development|
|cell-cell signaling|
|mitochondrion|
|transmembrane transport|
|regulation of organelle organization|
|defense response|
|ion transport|
|nervous system process|
|small molecule metabolic process|
|tissue development|
|cellular catabolic process|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-2.58|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-2.11|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.1|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.78|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.71|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.72|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.74|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.79|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|1.79|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.82|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.83|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.85|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.86|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.88|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.89|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.99|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|2.1|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.28|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.54|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.59|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pgp|PGP]]|0.429|
|[[:human genes:h:hk2|HK2]]|0.426|
|[[:human genes:p:pfkp|PFKP]]|0.422|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7950
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VDAC1 Expression in NALM6 Cells: 9.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>