VEGFB [The Human Chemical-Genetic Interaction Map Project]

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======= VEGFB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VEGFB
  * **<color #00a2e8>Official Name</color>**: vascular endothelial growth factor B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7423|7423]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49765|P49765]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VEGFB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VEGFB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601398|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vascular endothelial growth factor receptor 1 binding|
|positive regulation of mast cell chemotaxis|
|vascular endothelial growth factor receptor binding|
|regulation of mast cell chemotaxis|
|induction of positive chemotaxis|
|vascular endothelial growth factor signaling pathway|
|positive regulation of positive chemotaxis|
|regulation of positive chemotaxis|
|chemoattractant activity|
|cellular response to vascular endothelial growth factor stimulus|
|coronary vasculature development|
|positive chemotaxis|
|sprouting angiogenesis|
|vascular endothelial growth factor receptor signaling pathway|
|platelet alpha granule lumen|
|cardiac muscle contraction|
|positive regulation of cell division|
|heart contraction|
|positive regulation of leukocyte chemotaxis|
|positive regulation of endothelial cell proliferation|
|heart process|
|striated muscle contraction|
|protein O-linked glycosylation|
|regulation of leukocyte chemotaxis|
|positive regulation of leukocyte migration|
|regulation of endothelial cell proliferation|
|platelet degranulation|
|positive regulation of chemotaxis|
|growth factor activity|
|positive regulation of angiogenesis|
|regulation of cell division|
|heparin binding|
|positive regulation of vasculature development|
|positive regulation of epithelial cell proliferation|
|regulation of leukocyte migration|
|regulation of chemotaxis|
|muscle contraction|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|regulation of angiogenesis|
|muscle system process|
|angiogenesis|
|regulation of vasculature development|
|glycoprotein biosynthetic process|
|regulation of epithelial cell proliferation|
|response to hypoxia|
|response to decreased oxygen levels|
|response to oxygen levels|
|glycoprotein metabolic process|
|blood circulation|
|circulatory system process|
|blood vessel morphogenesis|
|blood vessel development|
|protein heterodimerization activity|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|heart development|
|response to growth factor|
|positive regulation of cellular component movement|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|positive regulation of response to external stimulus|
|carbohydrate derivative biosynthetic process|
|tube morphogenesis|
|regulated exocytosis|
|enzyme linked receptor protein signaling pathway|
|exocytosis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|positive regulation of protein phosphorylation|
|response to drug|
|carbohydrate derivative metabolic process|
|export from cell|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|response to abiotic stimulus|
|positive regulation of protein modification process|
|locomotion|
|positive regulation of developmental process|
|organonitrogen compound biosynthetic process|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|extracellular region|
|vesicle-mediated transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3856
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VEGFB Expression in NALM6 Cells: 4.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>