VIM [The Human Chemical-Genetic Interaction Map Project]

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======= VIM =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VIM
  * **<color #00a2e8>Official Name</color>**: vimentin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7431|7431]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08670|P08670]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VIM&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VIM|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/193060|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a type III intermediate filament protein. Intermediate filaments, along with microtubules and actin microfilaments, make up the cytoskeleton. The encoded protein is responsible for maintaining cell shape and integrity of the cytoplasm, and stabilizing cytoskeletal interactions. This protein is involved in neuritogenesis and cholesterol transport and functions as an organizer of a number of other critical proteins involved in cell attachment, migration, and signaling. Bacterial and viral pathogens have been shown to attach to this protein on the host cell surface. Mutations in this gene are associated with congenital cataracts in human patients. [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Filament head|
|Filament|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|keratin filament binding|
|Bergmann glial cell differentiation|
|cellular response to muramyl dipeptide|
|lens fiber cell development|
|response to muramyl dipeptide|
|intermediate filament organization|
|structural constituent of eye lens|
|positive regulation of collagen biosynthetic process|
|positive regulation of collagen metabolic process|
|lens fiber cell differentiation|
|regulation of collagen biosynthetic process|
|astrocyte development|
|actin-myosin filament sliding|
|muscle filament sliding|
|regulation of collagen metabolic process|
|cell leading edge|
|polysome|
|intermediate filament cytoskeleton organization|
|intermediate filament-based process|
|astrocyte differentiation|
|SMAD protein signal transduction|
|scaffold protein binding|
|phagocytic vesicle|
|double-stranded RNA binding|
|lens development in camera-type eye|
|actin-mediated cell contraction|
|structural constituent of cytoskeleton|
|glial cell development|
|peroxisome|
|nuclear matrix|
|actin filament-based movement|
|intermediate filament|
|positive regulation of translation|
|positive regulation of cellular amide metabolic process|
|negative regulation of neuron projection development|
|ribonucleoprotein complex|
|cellular response to interferon-gamma|
|glial cell differentiation|
|regulation of mRNA stability|
|response to interferon-gamma|
|negative regulation of cell projection organization|
|regulation of RNA stability|
|cellular response to lipopolysaccharide|
|epithelial cell development|
|cellular response to molecule of bacterial origin|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of mRNA catabolic process|
|gliogenesis|
|cellular response to biotic stimulus|
|negative regulation of neuron differentiation|
|protein domain specific binding|
|muscle contraction|
|negative regulation of neurogenesis|
|muscle system process|
|negative regulation of nervous system development|
|camera-type eye development|
|response to lipopolysaccharide|
|neuron projection|
|cellular response to peptide|
|response to molecule of bacterial origin|
|regulation of mRNA metabolic process|
|negative regulation of cell development|
|regulation of translation|
|eye development|
|visual system development|
|cytoskeleton|
|sensory system development|
|regulation of cellular amide metabolic process|
|cellular response to drug|
|focal adhesion|
|supramolecular fiber organization|
|response to peptide|
|regulation of neuron projection development|
|cellular response to lipid|
|posttranscriptional regulation of gene expression|
|sensory organ development|
|actin filament-based process|
|cellular response to organonitrogen compound|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|cytokine-mediated signaling pathway|
|epithelial cell differentiation|
|response to bacterium|
|regulation of plasma membrane bounded cell projection organization|
|viral process|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|innate immune response|
|symbiotic process|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|response to lipid|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|defense response to other organism|
|central nervous system development|
|regulation of catabolic process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|response to drug|
|cellular response to oxygen-containing compound|
|identical protein binding|
|response to nitrogen compound|
|response to cytokine|
|cytoskeleton organization|
|epithelium development|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|response to endogenous stimulus|
|generation of neurons|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cell development|
|positive regulation of protein metabolic process|
|tissue development|
|regulation of cell differentiation|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5706
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VIM Expression in NALM6 Cells: 8.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>