VPS26A [The Human Chemical-Genetic Interaction Map Project]

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======= VPS26A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VPS26A
  * **<color #00a2e8>Official Name</color>**: VPS26, retromer complex component A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9559|9559]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75436|O75436]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VPS26A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VPS26A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605506|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:15078902, PubMed:15078903). Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922). Required for the endosomal localization of WASHC2A (indicative for the WASH complex) (PubMed:22070227). Required for the endosomal localization of TBC1D5 (PubMed:20923837). Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed:22279231). Involved in retromer- independent lysosomal sorting of F2R (PubMed:16407403). Involved in recycling of ADRB2 (PubMed:21602791). Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity). {ECO:0000250|UniProtKB:P40336, ECO:0000269|PubMed:15078902, ECO:0000269|PubMed:15078903, ECO:0000269|PubMed:15247922, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:22070227, ECO:0000269|PubMed:22279231, ECO:0000303|PubMed:20923837, ECO:0000303|PubMed:21602791, ECO:0000303|PubMed:21725319, ECO:0000303|PubMed:23563491, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Vps26|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|retromer, cargo-selective complex|
|tubular endosome|
|retromer complex|
|retrograde transport, endosome to plasma membrane|
|retrograde transport, endosome to Golgi|
|vesicle-mediated transport to the plasma membrane|
|vesicle|
|cytosolic transport|
|regulation of macroautophagy|
|endosome membrane|
|endosomal transport|
|lysosome|
|early endosome|
|endosome|
|regulation of autophagy|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of cellular catabolic process|
|intracellular protein transport|
|regulation of catabolic process|
|cell-cell signaling|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-2.13|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.99|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.98|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.95|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.88|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|-1.87|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.87|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-1.83|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.82|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|-1.79|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.74|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.73|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.72|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.71|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.7|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.8|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:v:vps35|VPS35]]|0.566|
|[[:human genes:v:vps29|VPS29]]|0.479|
|[[:human genes:w:wdr24|WDR24]]|0.435|
|[[:human genes:v:vps41|VPS41]]|0.407|
|[[:human genes:c:c20orf24|C20orf24]]|0.404|
|[[:human genes:d:dpagt1|DPAGT1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3969
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VPS26A Expression in NALM6 Cells: 5.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>