VPS37B [The Human Chemical-Genetic Interaction Map Project]

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======= VPS37B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VPS37B
  * **<color #00a2e8>Official Name</color>**: VPS37B subunit of ESCRT-I
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79720|79720]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H9H4|Q9H9H4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VPS37B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VPS37B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610037|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. {ECO:0000269|PubMed:15218037}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mod r|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of viral budding via host ESCRT complex|
|regulation of viral budding via host ESCRT complex|
|ESCRT I complex|
|positive regulation of viral release from host cell|
|viral budding via host ESCRT complex|
|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|
|endosome transport via multivesicular body sorting pathway|
|viral budding|
|multivesicular body assembly|
|multivesicular body organization|
|regulation of viral release from host cell|
|multivesicular body sorting pathway|
|protein targeting to vacuole|
|virion assembly|
|establishment of protein localization to vacuole|
|intracellular transport of virus|
|host cell|
|transport of virus|
|positive regulation of viral life cycle|
|calcium-dependent protein binding|
|protein localization to vacuole|
|multi-organism localization|
|multi-organism transport|
|endosome organization|
|positive regulation of viral process|
|late endosome membrane|
|vacuolar transport|
|regulation of viral life cycle|
|midbody|
|protein targeting to membrane|
|macroautophagy|
|viral life cycle|
|regulation of viral process|
|endosome membrane|
|regulation of symbiosis, encompassing mutualism through parasitism|
|endosomal transport|
|autophagy|
|process utilizing autophagic mechanism|
|establishment of protein localization to membrane|
|endosome|
|vesicle organization|
|protein targeting|
|endomembrane system organization|
|establishment of protein localization to organelle|
|protein localization to membrane|
|positive regulation of multi-organism process|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|positive regulation of locomotion|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|intracellular membrane-bounded organelle|
|viral process|
|protein localization to organelle|
|organelle assembly|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|cellular macromolecule catabolic process|
|regulation of locomotion|
|intracellular protein transport|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|proteolysis|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-2.2|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-1.98|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-1.91|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.78|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.76|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.71|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.71|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.78|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.98|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.45|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|2.91|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|3.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7517
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VPS37B Expression in NALM6 Cells: 6.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>