VTN [The Human Chemical-Genetic Interaction Map Project]

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======= VTN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VTN
  * **<color #00a2e8>Official Name</color>**: vitronectin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7448|7448]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04004|P04004]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VTN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VTN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/193190|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Somatomedin B|
|Hemopexin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|smooth muscle cell-matrix adhesion|
|rough endoplasmic reticulum lumen|
|alphav-beta3 integrin-vitronectin complex|
|positive regulation of vascular endothelial growth factor receptor signaling pathway|
|polysaccharide binding|
|cell adhesion mediated by integrin|
|extracellular matrix binding|
|liver regeneration|
|regulation of vascular endothelial growth factor receptor signaling pathway|
|positive regulation of smooth muscle cell migration|
|endodermal cell differentiation|
|endoderm formation|
|negative regulation of blood coagulation|
|scavenger receptor activity|
|negative regulation of hemostasis|
|positive regulation of receptor-mediated endocytosis|
|negative regulation of coagulation|
|positive regulation of wound healing|
|regulation of smooth muscle cell migration|
|collagen binding|
|positive regulation of response to wounding|
|oligodendrocyte differentiation|
|negative regulation of wound healing|
|endoderm development|
|animal organ regeneration|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|negative regulation of response to wounding|
|protein polymerization|
|basement membrane|
|positive regulation of protein binding|
|regulation of receptor-mediated endocytosis|
|positive regulation of endocytosis|
|Golgi lumen|
|formation of primary germ layer|
|regulation of complement activation|
|positive regulation of cell-substrate adhesion|
|liver development|
|cell-matrix adhesion|
|hepaticobiliary system development|
|integrin binding|
|extracellular matrix structural constituent|
|regulation of humoral immune response|
|regulation of wound healing|
|blood microparticle|
|regeneration|
|gastrulation|
|regulation of response to wounding|
|heparin binding|
|glial cell differentiation|
|positive regulation of binding|
|cell-substrate adhesion|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of endocytosis|
|regulation of cell-substrate adhesion|
|gliogenesis|
|regulation of protein binding|
|negative regulation of endopeptidase activity|
|regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of peptidase activity|
|regulation of cellular response to growth factor stimulus|
|extracellular matrix organization|
|negative regulation of proteolysis|
|negative regulation of response to external stimulus|
|collagen-containing extracellular matrix|
|regulation of binding|
|extracellular structure organization|
|positive regulation of cell adhesion|
|gland development|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|regulation of immune effector process|
|regulation of body fluid levels|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|cell population proliferation|
|endocytosis|
|embryonic morphogenesis|
|import into cell|
|regulation of cell adhesion|
|intracellular membrane-bounded organelle|
|regulation of proteolysis|
|negative regulation of catalytic activity|
|cellular protein-containing complex assembly|
|regulation of cell migration|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|cell migration|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|identical protein binding|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|locomotion|
|regulation of protein phosphorylation|
|regulation of response to stress|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-2.03|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.8|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12506
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VTN Expression in NALM6 Cells: -2.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>