WBP4 [The Human Chemical-Genetic Interaction Map Project]

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======= WBP4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WBP4
  * **<color #00a2e8>Official Name</color>**: WW domain binding protein 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11193|11193]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75554|O75554]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WBP4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WBP4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604981|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Promotes pre-mRNA splicing. A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex. {ECO:0000269|PubMed:19592703, ECO:0000269|PubMed:9724750}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WW|
|zf-U1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|proline-rich region binding|
|mRNA cis splicing, via spliceosome|
|U2-type precatalytic spliceosome|
|nucleic acid binding|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|mRNA metabolic process|
|zinc ion binding|
|RNA processing|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-1.8|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.75|
|[[:results:exp114|A-196 10μM R03 exp114]]|-1.72|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.7|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|1.71|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.73|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.76|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.79|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.98|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2.05|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.05|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.08|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.35|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.43|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.74|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.83|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.94|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.98|
|[[:results:exp504|MK2206 4μM R08 exp504]]|3.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:katna1|KATNA1]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9939
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WBP4 Expression in NALM6 Cells: 4.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>