WDR36 [The Human Chemical-Genetic Interaction Map Project]

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======= WDR36 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDR36
  * **<color #00a2e8>Official Name</color>**: WD repeat domain 36
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=134430|134430]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NI36|Q8NI36]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDR36&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDR36|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609669|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG). [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2. {ECO:0000269|PubMed:21051332}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
|Utp21|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Pwp2p-containing subcomplex of 90S preribosome|
|small-subunit processome|
|retina homeostasis|
|regulation of axon extension|
|regulation of extent of cell growth|
|regulation of cell size|
|regulation of axonogenesis|
|tissue homeostasis|
|rRNA processing|
|visual perception|
|rRNA metabolic process|
|sensory perception of light stimulus|
|ribosome biogenesis|
|regulation of cell morphogenesis involved in differentiation|
|multicellular organismal homeostasis|
|regulation of developmental growth|
|anatomical structure homeostasis|
|regulation of cellular component size|
|ncRNA processing|
|regulation of cell growth|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|regulation of anatomical structure size|
|regulation of neuron differentiation|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of neurogenesis|
|nucleolus|
|RNA processing|
|regulation of nervous system development|
|regulation of cell development|
|sensory perception|
|regulation of anatomical structure morphogenesis|
|nervous system process|
|RNA binding|
|generation of neurons|
|neurogenesis|
|homeostatic process|
|RNA metabolic process|
|regulation of cell differentiation|
|system process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|1.86|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.89|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1264
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDR36 Expression in NALM6 Cells: 7.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>