WDR3 [The Human Chemical-Genetic Interaction Map Project]

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======= WDR3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDR3
  * **<color #00a2e8>Official Name</color>**: WD repeat domain 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10885|10885]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UNX4|Q9UNX4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDR3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDR3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604737|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Utp12|
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Pwp2p-containing subcomplex of 90S preribosome|
|small-subunit processome|
|rRNA processing|
|rRNA metabolic process|
|nuclear membrane|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-2.27|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.83|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|1.73|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:ddx56|DDX56]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 550/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|19/28|
|blood|15/28|
|bone|17/26|
|breast|22/33|
|central nervous system|42/56|
|cervix|2/4|
|colorectal|14/17|
|esophagus|12/13|
|fibroblast|0/1|
|gastric|10/16|
|kidney|17/21|
|liver|16/20|
|lung|61/75|
|lymphocyte|14/16|
|ovary|18/26|
|pancreas|19/24|
|peripheral nervous system|13/16|
|plasma cell|13/15|
|prostate|0/1|
|skin|18/24|
|soft tissue|7/9|
|thyroid|2/2|
|upper aerodigestive|17/22|
|urinary tract|22/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 117
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDR3 Expression in NALM6 Cells: 7.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>