WDR55 [The Human Chemical-Genetic Interaction Map Project]

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======= WDR55 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDR55
  * **<color #00a2e8>Official Name</color>**: WD repeat domain 55
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54853|54853]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H6Y2|Q9H6Y2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDR55&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDR55|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620832|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity). {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|ncRNA processing|
|cellular component|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|molecular function|
|nucleolus|
|RNA processing|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-2.13|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-2.03|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.89|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-1.86|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|-1.83|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.8|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.73|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 646/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|27/28|
|bone|22/26|
|breast|26/33|
|central nervous system|53/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|12/16|
|kidney|16/21|
|liver|17/20|
|lung|66/75|
|lymphocyte|16/16|
|ovary|24/26|
|pancreas|20/24|
|peripheral nervous system|14/16|
|plasma cell|13/15|
|prostate|0/1|
|skin|22/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|26/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 733
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDR55 Expression in NALM6 Cells: 6.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>