WDR5 [The Human Chemical-Genetic Interaction Map Project]

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======= WDR5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDR5
  * **<color #00a2e8>Official Name</color>**: WD repeat domain 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11091|11091]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61964|P61964]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDR5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDR5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609012|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation. {ECO:0000269|PubMed:16600877, ECO:0000269|PubMed:16829960, ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:20018852}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|eIF2A|
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|
|regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter|
|histone acetyltransferase activity (H4-K5 specific)|
|histone acetyltransferase activity (H4-K16 specific)|
|histone acetyltransferase activity (H4-K8 specific)|
|regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter|
|Set1C/COMPASS complex|
|positive regulation of gluconeogenesis|
|MLL3/4 complex|
|histone H4-K8 acetylation|
|histone methyltransferase activity (H3-K4 specific)|
|histone H4-K5 acetylation|
|Ada2/Gcn5/Ada3 transcription activator complex|
|histone H4-K16 acetylation|
|histone acetyltransferase complex|
|MLL1 complex|
|histone H3-K4 methylation|
|positive regulation of glucose metabolic process|
|histone methyltransferase complex|
|regulation of gluconeogenesis|
|histone H3 acetylation|
|regulation of megakaryocyte differentiation|
|histone H4 acetylation|
|positive regulation of cellular carbohydrate metabolic process|
|methylated histone binding|
|histone lysine methylation|
|positive regulation of carbohydrate metabolic process|
|peptidyl-lysine methylation|
|histone methylation|
|regulation of carbohydrate biosynthetic process|
|regulation of glucose metabolic process|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|histone binding|
|protein methylation|
|protein alkylation|
|positive regulation of small molecule metabolic process|
|regulation of cellular carbohydrate metabolic process|
|protein acetylation|
|protein acylation|
|regulation of carbohydrate metabolic process|
|regulation of myeloid cell differentiation|
|macromolecule methylation|
|methylation|
|peptidyl-lysine modification|
|post-translational protein modification|
|histone modification|
|covalent chromatin modification|
|regulation of small molecule metabolic process|
|regulation of hemopoiesis|
|skeletal system development|
|neuron projection development|
|chromatin organization|
|neuron development|
|peptidyl-amino acid modification|
|neuron differentiation|
|chromosome organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of transcription by RNA polymerase II|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of immune system process|
|positive regulation of RNA metabolic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.8|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.7|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|1.72|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.74|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.82|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.83|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.88|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.9|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.98|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.99|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.99|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.04|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.15|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.2|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.76|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|2.8|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|3.4|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:zzz3|ZZZ3]]|0.47|
|[[:human genes:y:yeats2|YEATS2]]|0.415|
|[[:human genes:t:tada2a|TADA2A]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 696/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|28/28|
|bone|25/25|
|breast|32/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|20/21|
|liver|19/20|
|lung|69/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|23/24|
|peripheral nervous system|16/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|19/24|
|soft tissue|6/7|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|27/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 135
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDR5 Expression in NALM6 Cells: 6.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>