WDR70 [The Human Chemical-Genetic Interaction Map Project]

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======= WDR70 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDR70
  * **<color #00a2e8>Official Name</color>**: WD repeat domain 70
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55100|55100]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NW82|Q9NW82]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDR70&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDR70|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617233|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of histone H2B conserved C-terminal lysine ubiquitination|
|regulation of DNA double-strand break processing|
|regulation of histone H2B ubiquitination|
|regulation of histone ubiquitination|
|site of double-strand break|
|regulation of double-strand break repair|
|regulation of DNA repair|
|regulation of histone modification|
|regulation of chromatin organization|
|regulation of protein ubiquitination|
|regulation of response to DNA damage stimulus|
|regulation of protein modification by small protein conjugation or removal|
|enzyme binding|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|regulation of cellular response to stress|
|regulation of organelle organization|
|regulation of response to stress|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 154/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|7/28|
|blood|9/28|
|bone|9/26|
|breast|13/33|
|central nervous system|10/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|2/20|
|lung|13/75|
|lymphocyte|7/16|
|ovary|6/26|
|pancreas|1/24|
|peripheral nervous system|5/16|
|plasma cell|5/15|
|prostate|1/1|
|skin|8/24|
|soft tissue|1/9|
|thyroid|1/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1160
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDR70 Expression in NALM6 Cells: 5.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>