WDR74 [The Human Chemical-Genetic Interaction Map Project]

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======= WDR74 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDR74
  * **<color #00a2e8>Official Name</color>**: WD repeat domain 74
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54663|54663]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6RFH5|Q6RFH5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDR74&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDR74|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617947|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear exosome (RNase complex)|
|preribosome, large subunit precursor|
|blastocyst formation|
|ribosomal large subunit biogenesis|
|blastocyst development|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|in utero embryonic development|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|nucleolus|
|RNA processing|
|anatomical structure formation involved in morphogenesis|
|embryo development|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp114|A-196 10μM R03 exp114]]|1.73|
|[[:results:exp483|FTY720 3μM R08 exp483]]|1.73|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.45|
|[[:human genes:p:prim1|PRIM1]]|0.446|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 724/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|30/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|24/26|
|pancreas|23/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 127
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDR74 Expression in NALM6 Cells: 6.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>