WIPI1 [The Human Chemical-Genetic Interaction Map Project]

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======= WIPI1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WIPI1
  * **<color #00a2e8>Official Name</color>**: WD repeat domain, phosphoinositide interacting 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55062|55062]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5MNZ9|Q5MNZ9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WIPI1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WIPI1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609224|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation- induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway. {ECO:0000269|PubMed:15020712, ECO:0000269|PubMed:15602573, ECO:0000269|PubMed:20114074, ECO:0000269|PubMed:20484055, ECO:0000269|PubMed:20639694, ECO:0000269|PubMed:21317285, ECO:0000269|PubMed:22829830, ECO:0000269|PubMed:23088497}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vesicle targeting, trans-Golgi to endosome|
|protein localization to phagophore assembly site|
|phagophore assembly site membrane|
|Golgi to endosome transport|
|phagophore assembly site|
|phosphatidylinositol-3,5-bisphosphate binding|
|autophagosome membrane|
|mitochondrion disassembly|
|autophagy of mitochondrion|
|phosphatidylinositol-3-phosphate binding|
|estrogen receptor binding|
|androgen receptor binding|
|IRE1-mediated unfolded protein response|
|clathrin-coated vesicle|
|autophagosome assembly|
|organelle disassembly|
|autophagosome organization|
|extrinsic component of membrane|
|vesicle targeting, to, from or within Golgi|
|protein lipidation|
|vesicle targeting|
|lipoprotein biosynthetic process|
|post-Golgi vesicle-mediated transport|
|endoplasmic reticulum unfolded protein response|
|lipoprotein metabolic process|
|cellular response to unfolded protein|
|vacuole organization|
|cytosolic transport|
|cellular response to topologically incorrect protein|
|cellular response to starvation|
|macroautophagy|
|response to unfolded protein|
|trans-Golgi network|
|establishment of vesicle localization|
|vesicle localization|
|response to topologically incorrect protein|
|response to starvation|
|endosome membrane|
|cellular response to nutrient levels|
|response to endoplasmic reticulum stress|
|autophagy|
|process utilizing autophagic mechanism|
|cellular response to extracellular stimulus|
|cellular response to external stimulus|
|signaling receptor binding|
|establishment of organelle localization|
|cytoskeleton|
|Golgi vesicle transport|
|cellular component disassembly|
|mitochondrion organization|
|response to nutrient levels|
|response to extracellular stimulus|
|organelle localization|
|Golgi membrane|
|organelle assembly|
|organonitrogen compound biosynthetic process|
|intracellular transport|
|cellular protein localization|
|cellular macromolecule localization|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|cellular catabolic process|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|1.71|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15929
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WIPI1 Expression in NALM6 Cells: 3.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>