WRAP53 [The Human Chemical-Genetic Interaction Map Project]

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======= WRAP53 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WRAP53
  * **<color #00a2e8>Official Name</color>**: WD repeat containing antisense to TP53
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55135|55135]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BUR4|Q9BUR4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WRAP53&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WRAP53|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612661|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post- transcriptional level; it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage. {ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19250907}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA folding|
|telomere formation via telomerase|
|telomerase RNA localization|
|protein localization to nuclear body|
|telomerase RNA localization to Cajal body|
|protein localization to Cajal body|
|protein localization to nucleoplasm|
|Cajal body organization|
|telomere assembly|
|RNA localization to nucleus|
|scaRNA localization to Cajal body|
|RNA localization to Cajal body|
|positive regulation of double-strand break repair via homologous recombination|
|positive regulation of establishment of protein localization to telomere|
|regulation of establishment of protein localization to telomere|
|positive regulation of protein localization to chromosome, telomeric region|
|regulation of establishment of protein localization to chromosome|
|positive regulation of double-strand break repair via nonhomologous end joining|
|regulation of protein localization to chromosome, telomeric region|
|nuclear body organization|
|telomerase holoenzyme complex|
|telomere maintenance via telomerase|
|telomerase RNA binding|
|regulation of double-strand break repair via nonhomologous end joining|
|telomere maintenance via telomere lengthening|
|positive regulation of double-strand break repair|
|RNA-dependent DNA biosynthetic process|
|positive regulation of telomerase activity|
|positive regulation of DNA recombination|
|regulation of double-strand break repair via homologous recombination|
|chromosome, telomeric region|
|regulation of telomerase activity|
|Cajal body|
|site of double-strand break|
|positive regulation of DNA repair|
|positive regulation of DNA biosynthetic process|
|regulation of double-strand break repair|
|telomere maintenance|
|positive regulation of response to DNA damage stimulus|
|telomere organization|
|chaperone binding|
|regulation of DNA recombination|
|DNA biosynthetic process|
|regulation of DNA biosynthetic process|
|regulation of DNA repair|
|histone binding|
|nucleus organization|
|protein localization to nucleus|
|positive regulation of DNA metabolic process|
|RNA localization|
|regulation of response to DNA damage stimulus|
|protein-containing complex binding|
|nuclear body|
|ubiquitin protein ligase binding|
|positive regulation of cellular protein localization|
|anatomical structure homeostasis|
|regulation of DNA metabolic process|
|positive regulation of establishment of protein localization|
|DNA repair|
|regulation of cellular protein localization|
|positive regulation of transferase activity|
|protein localization to organelle|
|regulation of cellular response to stress|
|DNA metabolic process|
|regulation of establishment of protein localization|
|cellular response to DNA damage stimulus|
|regulation of cellular localization|
|regulation of transferase activity|
|regulation of protein localization|
|chromosome organization|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|RNA binding|
|positive regulation of catalytic activity|
|regulation of response to stress|
|cellular protein localization|
|cellular macromolecule localization|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.06|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.77|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1885
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WRAP53 Expression in NALM6 Cells: 5.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>