WWTR1 [The Human Chemical-Genetic Interaction Map Project]

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======= WWTR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WWTR1
  * **<color #00a2e8>Official Name</color>**: WW domain containing transcription regulator 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25937|25937]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9GZV5|Q9GZV5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WWTR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WWTR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607392|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. {ECO:0000269|PubMed:11118213, ECO:0000269|PubMed:18227151, ECO:0000269|PubMed:18568018, ECO:0000269|PubMed:19010321}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WW|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of metanephric nephron tubule epithelial cell differentiation|
|regulation of nephron tubule epithelial cell differentiation|
|regulation of epithelial cell differentiation involved in kidney development|
|regulation of SMAD protein signal transduction|
|regulation of metanephros development|
|hippo signaling|
|stem cell division|
|negative regulation of fat cell differentiation|
|positive regulation of epithelial to mesenchymal transition|
|glomerulus development|
|regulation of kidney development|
|multicellular organism growth|
|regulation of epithelial to mesenchymal transition|
|kidney morphogenesis|
|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|
|heart process|
|regulation of fat cell differentiation|
|nephron development|
|osteoblast differentiation|
|regulation of epithelial cell differentiation|
|mesenchymal cell differentiation|
|negative regulation of canonical Wnt signaling pathway|
|transcription initiation from RNA polymerase II promoter|
|tissue homeostasis|
|transcription factor complex|
|negative regulation of Wnt signaling pathway|
|DNA-templated transcription, initiation|
|mesenchyme development|
|negative regulation of protein kinase activity|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|transcription corepressor activity|
|negative regulation of kinase activity|
|ossification|
|kidney development|
|negative regulation of transferase activity|
|regulation of canonical Wnt signaling pathway|
|nuclear body|
|transcription coactivator activity|
|renal system development|
|urogenital system development|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|multicellular organismal homeostasis|
|anatomical structure homeostasis|
|cilium assembly|
|proteasomal protein catabolic process|
|regulation of Wnt signaling pathway|
|cilium organization|
|developmental growth|
|growth|
|circulatory system process|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|transcription by RNA polymerase II|
|cell division|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|proteolysis involved in cellular protein catabolic process|
|negative regulation of protein modification process|
|cellular protein catabolic process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|protein catabolic process|
|protein ubiquitination|
|negative regulation of cell differentiation|
|organelle assembly|
|protein modification by small protein conjugation|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|negative regulation of transcription by RNA polymerase II|
|regulation of kinase activity|
|protein homodimerization activity|
|cellular macromolecule catabolic process|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|proteolysis|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|RNA metabolic process|
|intracellular signal transduction|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 64/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|0/28|
|bone|1/25|
|breast|0/33|
|central nervous system|7/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|1/15|
|kidney|3/21|
|liver|3/20|
|lung|8/75|
|lymphocyte|0/14|
|ovary|4/26|
|pancreas|2/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|7/24|
|soft tissue|1/7|
|thyroid|1/2|
|upper aerodigestive|3/22|
|urinary tract|1/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11316
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WWTR1 Expression in NALM6 Cells: 1.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>