XG [The Human Chemical-Genetic Interaction Map Project]

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======= XG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: XG
  * **<color #00a2e8>Official Name</color>**: Xg glycoprotein (Xg blood group)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7499|7499]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55808|P55808]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=XG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20XG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300879|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the XG blood group antigen, and is located at the pseudoautosomal boundary on the short (p) arm of chromosome X. The three 5' exons reside in the pseudoautosomal region and the remaining exons within the X-specific end. A truncated copy of this gene is found on the Y chromosome at the pseudoautosomal boundary. It is transcribed, but not expected to make a Y-chromosome specific gene product. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008].  Sequence Note: This RefSeq record represents the XG*001.1.1 allele. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CD99L2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of neutrophil extravasation|
|T cell extravasation|
|regulation of neutrophil extravasation|
|positive regulation of cellular extravasation|
|T cell migration|
|positive regulation of neutrophil migration|
|regulation of cellular extravasation|
|regulation of neutrophil migration|
|cellular extravasation|
|homotypic cell-cell adhesion|
|lymphocyte migration|
|positive regulation of leukocyte migration|
|regulation of leukocyte migration|
|leukocyte migration|
|positive regulation of cell migration|
|cell-cell adhesion|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|molecular function|
|regulation of cell migration|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|cell motility|
|localization of cell|
|positive regulation of immune system process|
|locomotion|
|integral component of plasma membrane|
|movement of cell or subcellular component|
|regulation of immune system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17698
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.07 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='XG Expression in NALM6 Cells: -1.07'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>